ID A0A1G9UPH7_9ACTO Unreviewed; 3188 AA.
AC A0A1G9UPH7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Fatty acid synthase {ECO:0000313|EMBL:SDM61754.1};
GN ORFNames=SAMN04487766_104188 {ECO:0000313|EMBL:SDM61754.1};
OS Actinomyces ruminicola.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=332524 {ECO:0000313|EMBL:SDM61754.1, ECO:0000313|Proteomes:UP000199671};
RN [1] {ECO:0000313|EMBL:SDM61754.1, ECO:0000313|Proteomes:UP000199671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KPR-7B {ECO:0000313|EMBL:SDM61754.1,
RC ECO:0000313|Proteomes:UP000199671};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
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DR EMBL; FNHU01000004; SDM61754.1; -; Genomic_DNA.
DR Proteomes; UP000199671; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.30.70.3320; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 2634..3094
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1798..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2484..2519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1800..1814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3188 AA; 331650 MW; 5BB02F7FC6A75B0D CRC64;
MTISPTSPTP KTTPIDPTTE DRMTTQPSTP ETIAERLNAG EPYVLAFGGQ ATPWRSTLEE
LAGLDRDLAA ELAAVDAAVA DRLAPVATDL LTVTPRGARF FTDAGAPVAP APQGTAGAAD
TADVSVPGIL FAQHAALACL PGSGIDPAGE HAPGAVIGHS QGVLGVALLD ALRQARSDGG
EAVTDAVVQV HAIARLIGAA AARTTGRLDL GTVGETTPML SVRGVTRDVL DGVLAQVPGS
ERIAVGVVNG RQAHILSGRP GDLERVITAL EAAARRSARD RKERRRGGAV LNPITEFLTT
SVPFHTPLLA GAVDDVVAWA ERAGLDAELA RDLAVAVLID PVDWPAIVAS ALGEGESVRR
LILDVGPGAV LSRLTEPVVA GTGTTVVPAG TASRIDDLDR PGAAPAPTVD RARFAPRLTQ
LPDGRITLDT AFTRLTGRSA ILLAGMTPTT VDPEIVAAAA NAGYWAELAG GGQTTAKVLA
DNLAGLEQAL EPGRTAAFNA MFMDRYLWNL HLGSQRLLSK ARAAGTPVDG VVISAGIPEL
DEAVSLITRL RAEGFPYVAF KPGTVDQIRQ VIAIARAVPD VPVIMQIEDG HAGGHHSWED
LDTMLLATYD AIRAVDNLVL CVGGGIGAPE RAADYITGRW ALAYGTAAAP VDGVCVGTAA
MTCLEAKTNE DVKQLLVDTP GIDPAHEGGW VASGASAGGM TSGLSHLRAD LYEIDNSSAR
ASRLIQELAG DDAAMTARRE EMIAALAKTA KPYFGDVEEM SYLEWATRYA QLCVAPHDGR
AATREDWADE GWYDRFLDLL HRVEARLSDA DHGEIPTLFA GEDDVLDADA ALAALAERYP
QSATTRVEPA DAAWFVDLCR KHPKPVPFVP VLDADILRWW GTDSLWQSQD PRYTADQVRI
IPGPVSVAGI TTINEPVGHL LGRFESAVIE ALEADGTPAA PAAGRIGTTL TAEARPVADA
TELVRATPHV LWNGHLTVNP ARVLADDAYR VVARPDVAAD AYDLDIHLDT HWDDTPGGEA
IHAVRRLVVP LRLARAWDGA APFVDPGRIS ETMNDLLRNT AGVGAVSVTG DLVDRLPEVV
APVAGATDAL GRPTDQPFGT VHARFTLADT LGADHAAVTA DALPTTLAAA PLVPDALLGP
CWPVVYAALG SVVEDGMPLI EGLLGAVHLD HTIDLRRPLA DLARDAGPDC VIQADGWVAA
LEESSAGRVV DVRLQLTDAA DGSLIALMRE RFAIRGRASG TAVPSAPEAA GGTGRATAPA
ARRLLRRITV SAPSDMTAFA RVTGDFNPIH TSYHAAKVAG MDAPLVHGMW LSATAQQAAA
ATGTDGTHHV LAGWTYTMLG PVELNDRVQI SVERTGLVVG GGQVLEVTCR VGDEVVSRGT
AVTEPEPTAY VYPGQGIQAR GMGLDEMRSS RAARAVWERA DAHTRAELGF SVIALVRDNP
TEMTARGVTY RHPDGLLNLT QFTQVALATV AMATTARLAE AGALVESAAF AGHSLGEYTA
LSAYGRVMSV ETTISIVFQR GSTMHSLVPR DDTGASNYRM GALRPNQAGI SAAEVEDYIR
GVSEASGEFL QIVNYNLAGV QYAVAGTIKG LEALAADARA KAAARGGKNP FMYVPGIDVP
FHSEVLRPGV PEFRERLLAL IPTDLDVERL VGRYVPNLVA RPFALTQDFA RAILEVVPSE
PVREIVDDWE QWASRPGDLG RQLLVELLAW QFASPVRWIE TQDVLLSAPE QGGLGVEHIV
EVGLAASPTL ANLASRTLAL PQHAGRHVVV HNARRDEARV LATDTDPAAG IEEEAAAQTT
VEVSEPTTSA PSAPTPAAAV EAAPAEAAPA AVSAPAASGP VADLPFGATD ALTALLAHAA
RIRPEQIAPT DTTETLTNGV SSRRNQLLMD LGTELQLASI DGAADADMST LAGIVAKGAP
GYKPFGPVLA DATRTGLGRI LGPSGVRAGR IADRVTGTWG LGDGWVSHVT AEIFLGTREG
SSMRGEDLAS LGSAEPLTSA GAVDALIDAA VQAVAGAHGV TVSMPSAGGG AGAVVDSAAL
DAFAAQVTGA DGVLATTART LLDALGLADK AGVPADAGDE ATATRAAVAA IDAELGTGWV
KSVTPAFSAE RAVLIDDRWA SARDDLARLG NGETDLETAA ALLEPQRFTG LGTAVADQAA
WWGRQLRAAA TAGGQADDLV RRAEIAEAIA AAAAQAPTAG ADSVRWADDV AVVTGVAPGS
IAAAVVGELL AGGATVVATS SRLTHERLAF ATRLYRDHAS AGARLWMVPA NLASYRDVDA
LADWIGNDQV VTSGGSTKLV KEALVPTLLF PFAAPRVVGT LADAGPAAES QTRLLLWSVE
RTIAALAAIG TDTHVDHRLH VVLPGSPNRG TFGGDGAYGE VKSALDAVVN RWRAEKNWSG
RVTLAHPRIG WVRGTGLMGG NDPLVQAVEA AGVRTWSTQE IAVELVELCT APVRERAADA
PVSADLTGGL GDDVDLVALR ESARAAAPAP QPEPEPQATV KALPTPQVPT QPTAPDWGEV
DADLDDLVVV VSTGEVSTWG SGRTRREAEL GMTAGDDVEL TAAGVLELAW GMGLLTWQDS
PKAGWYDTEG EFVDESDIYT RYRDEVVARC GIREFVDDGV IATEGPEEVA VYLDHDITLT
VADEATARTI EVTDPEHTLV APELADGAPT GEWTVTRLAG SLARVPRRAT LSRTVGGQFP
VDFDPERWGI PASMVQGMDT IASWNLVTAV DAFLSAGFSP AELLAAVHPS DVASTQGTGF
GGMESMRKMF VGRFLGEERP SDILQEALPN VVAAHVMQSY VGGYGSMVQP VSACATAAVS
IEEGWDKIAL GKADVVVAGA IDDISIESVV GFGNMNATAE AEAMYAKGIS ARHFSRANDR
RRGGFVEAEG GGTVILARGS VAARLGLPVA GVIGFVSSYA DGAHTSIPAP GLGALGAGRG
GKDSRLAKAL ARLGVEADDI AVVSKHDTST GANDPNESEL HTRLARALGR SEGNPLVAVS
QKTITGHAKG GAALFQVAGL AEILATGIAP GNASLDVVDA PLEKDAFWVW PRTAIRLAGR
GGAGGRVPGA GPVRAGLLTS LGFGHVSGLI AIVHPGAFEA ALRAQGGQEA VDSWVASANR
RLAAGTRRRR AGMIGRAPLF EQIDGRRLGE ERKGRDPHEV EAAMLLDPQA RLGADGVYHT
GEATGRHA
//
