ID A0A1G9VIG0_9EURY Unreviewed; 446 AA.
AC A0A1G9VIG0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN ORFNames=SAMN04487949_2389 {ECO:0000313|EMBL:SDM71821.1};
OS Halogranum gelatinilyticum.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae.
OX NCBI_TaxID=660521 {ECO:0000313|EMBL:SDM71821.1, ECO:0000313|Proteomes:UP000199451};
RN [1] {ECO:0000313|Proteomes:UP000199451}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.10119 {ECO:0000313|Proteomes:UP000199451};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNHL01000003; SDM71821.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9VIG0; -.
DR STRING; 660521.SAMN04487949_2389; -.
DR OrthoDB; 195185at2157; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000199451; Unassembled WGS sequence.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF1; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000199451}.
FT DOMAIN 183..436
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 446 AA; 48033 MW; A6E68D7F19E0A075 CRC64;
MGAPQRDPAT VSDGLVSRAV QISPPPFRAV LADADAPRTV WSAPDEATVV GSGTAATLTA
DGPDRFQRIR DRAEALFATG DVHAGTEAAC PRLFGGFAFH DDGAERPPWT DFPGARFVFP
RVQVTYADNG TWLTVNAVGP DVTPEAVEDR LEQERDRLES LPDPGPVCDP PGVRDRTRTT
DLDDWRAGVD AAVSRIRSGE LRKVVLAQAL ECSLDSELSI PDILDRLAGK YPDCHRFLVE
PVSGDASFFG ATPERLVTLH GRTVETGALA GTTGRGETPA EDEWLAEELM DSEKNVHEHE
LVADAIRDQL SPFTASMSTG NRTVRRLATV QHLWTPITAE LAGDQHVLDL VEALHPTPAV
GGLPPEKALD TIRDTEPFDR GWYAAPVGWI DAAGNGSFAV ALRSAVASGD VATLFAGVGV
VADSDPDREW DEVQLKYRPI LDELEN
//
