ID   A0A1G9WTB1_9BACL        Unreviewed;       342 AA.
AC   A0A1G9WTB1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   ORFNames=SAMN04487897_101336 {ECO:0000313|EMBL:SDM87481.1};
OS   Paenibacillus sp. yr247.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1761880 {ECO:0000313|EMBL:SDM87481.1, ECO:0000313|Proteomes:UP000198936};
RN   [1] {ECO:0000313|EMBL:SDM87481.1, ECO:0000313|Proteomes:UP000198936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YR247 {ECO:0000313|EMBL:SDM87481.1,
RC   ECO:0000313|Proteomes:UP000198936};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; FNIF01000001; SDM87481.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G9WTB1; -.
DR   STRING; 1761880.SAMN04487897_101336; -.
DR   OrthoDB; 9783139at2; -.
DR   Proteomes; UP000198936; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198936};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          1..72
FT                   /note="Winged helix-turn-helix transcription repressor HrcA
FT                   DNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03444"
FT   DOMAIN          105..322
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   342 AA;  38148 MW;  7AAD0B07BCDE955D CRC64;
     MLTERQRMIL SAIIDDYVRS AEPIGSRSIS KRGNVGFSPA TIRNEMSDLE EMGYLEQPHT
     SAGRIPSHKG YRYYVDHLLQ HGTLHNNDLD SMKGAFAERI QEMEGVIQHV AGMLSSLTNY
     TSIVLGPEVF STTLKHLQII PLTETTAVAI IVMNTGHVEN KTVSIPEGIP MSEIEKVVNI
     LNARLKNVPL IQFKSRLYNE ISNELSKYVN GYQELLSVVE SVLQSNEKDR VFLSGMTNML
     TQPEFKDVEK VKSIFDLLEE APTLIKLFTP SNEGIEIKIG AENSIEAINN CSLITASYSI
     GGKPLGTIGI LGPTRMEYGR VINLMEHLSK HLEVVLGRWY GK
//