ID A0A1G9X490_9GAMM Unreviewed; 732 AA.
AC A0A1G9X490;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=SAMN04487951_101127 {ECO:0000313|EMBL:SDM91594.1};
OS Halomonas arcis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=416873 {ECO:0000313|EMBL:SDM91594.1, ECO:0000313|Proteomes:UP000199677};
RN [1] {ECO:0000313|Proteomes:UP000199677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.6494 {ECO:0000313|Proteomes:UP000199677};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FNII01000001; SDM91594.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9X490; -.
DR STRING; 416873.SAMN04487951_101127; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000199677; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199677}.
FT DOMAIN 9..287
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 288..571
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 732 AA; 82626 MW; 16B00BC6082D658F CRC64;
MDDVTAILDQ LNADQREAVS ASQGNLLVLA GAGSGKTRVL VHRIAWLMQA EGLSPYALLA
VTFTNKAARE MRTRLEALLG LSLRHVWVGT FHSISHRLLR THWQDARLPQ HFQIIDADDQ
LRLVKRLLKD YSIDDERFPP RQVQGFISGC KEEGLRPHQV NVDGDAYLGQ MVELYERYQL
TCERGGLVDF GELLLRSLEL LRDNPALLAH YRERFGHLLV DEFQDTNTLQ YAWLKLITGM
QTPMTVVGDD DQSIYGWRGA KVENIRRFEQ EFPQTHTVRL EQNYRSTSAI LDAANALISH
NSERMGKQLW TEGSEGEPIS IYAGFNDIEE ARFIVDTIKE KVDEGLNRRD MAILYRSNAQ
SRLLEETLIR QGMPYRIYGG HRFYERLEIK NALAYLRLLL NRDDDASLER VINVPTRGIG
TRTVEIVRLR AREQNIPLWQ ALHDAMQDGT LKGRAGNAVQ AFANLIEQLD NDAAGLPLHE
IIDHVTDHTG LIEHHKSERG EKGQARVENL EELVNAARAF THGDAFETPE AGEGMAALEA
FLSEAALNAG DHEAEEFEDS VQLMTLHSAK GLEFPVVFIA GVEEGLFPHK MSLEEPGRLE
EERRLCYVGV TRAMQKLYLT HAETRRLHGK EVFPRPSRFI RELPPHLLEE VRLRGHISRP
VTASRTSFAQ QSVESDGDLP SLHVGQGVEH PVFGEGIILN AEGEGARARV QVSFEGEGVK
WLVLGFAKLT PL
//
