ID A0A1G9XIK3_9ACTN Unreviewed; 676 AA.
AC A0A1G9XIK3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Squalene-hopene/tetraprenyl-beta-curcumene cyclase {ECO:0000313|EMBL:SDM96266.1};
GN ORFNames=SAMN05444921_11622 {ECO:0000313|EMBL:SDM96266.1};
OS Streptomyces wuyuanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1196353 {ECO:0000313|EMBL:SDM96266.1, ECO:0000313|Proteomes:UP000199063};
RN [1] {ECO:0000313|Proteomes:UP000199063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7042 {ECO:0000313|Proteomes:UP000199063};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
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DR EMBL; FNHI01000016; SDM96266.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9XIK3; -.
DR STRING; 1196353.SAMN05444921_11622; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000199063; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000199063};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..329
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 350..665
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 74445 MW; 604BB540CD9973FA CRC64;
MTATTDGSGG TPASRAASAS DRTTDHRTTP GDPGNLGTTA LLTAQRSVEH LLGRQDAQGW
WKADLETNVT MDAEDLLLRQ FLGIQDEKTT AAAAVFIRGE QREDGTWATF YGGPGELSTT
IEAYVALRLA GDRPDDPHME RAAAWVRAQG GLAASRVFTR IWLALFGWWK WEDLPELPPE
LMYLPSWFPL NIYDFGCWAR QTIVPLTVVS AERPVRPAPF ALDELHTDRH HPNPPRPLAP
AASWDGLFQR LDRLLHGYHK VALRPLRRAA MNRAARWIIE RQENDGCWGG IQPPAVYSVI
ALHLLGYDLD HPVMRAGLES LDRFAVWRDE STGPGGRQEG PARMIEACQS PVWDTCLTVV
ALSDAGVPGD HPALVRAADW MLGEQITRPG DWAVRRPRLA PGGWAFEFHN DNYPDVDDTA
EVVLALRRVK HPDPSRVEEA VARAGNWTLG MQSKSGAWGA FDADNTGTFP NRLPFCDFGE
VIDPPSADVT AHVVEMLAHE GRAHHPRARR GVEWLLREQE PNGAWFGRWG VNHLYGTGAV
VPALVAAGVP VSHPAIRRAV GWLESVQNDD GGWGEDLRSY REEAWIGRGV STPSQTGWAL
LALLAAGERG GAAVGRGVSF LAATQREDGS WDEPYFTGTG FPWDFSINYH IYRQVFPLMA
LGRYVHGEPS TGRNGA
//
