ID A0A1G9XWG9_9EURY Unreviewed; 904 AA.
AC A0A1G9XWG9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN04487949_3157 {ECO:0000313|EMBL:SDN01138.1};
OS Halogranum gelatinilyticum.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae.
OX NCBI_TaxID=660521 {ECO:0000313|EMBL:SDN01138.1, ECO:0000313|Proteomes:UP000199451};
RN [1] {ECO:0000313|Proteomes:UP000199451}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.10119 {ECO:0000313|Proteomes:UP000199451};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNHL01000004; SDN01138.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9XWG9; -.
DR STRING; 660521.SAMN04487949_3157; -.
DR OrthoDB; 146065at2157; -.
DR Proteomes; UP000199451; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000199451}.
FT DOMAIN 702..718
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 833..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..865
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 628..635
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 904 AA; 98650 MW; F74BB4519E5CCA64 CRC64;
MTSVTGPPDQ MVAVRDELTP MMSQYLGLCE DYEDSLVLFQ VGDFYEAFCE AAEEVARICE
ITLTKREDST GTYPMSGIPI DNAASYLERL LDAGYRVAIA DQVEDASEAS GLVDRAVTQI
ITPGTIVDDE LLSAGTTNYV ASVARDEDVF SLAAVDVSTG ECLVTSADRE RIAEELERVA
PAELLFAPGV DAAEFDPDTL AAGAMVTDFD PDAFARDAAH DTLAGYVPSP DAVVATDAEL
RACGGLLAYA EYTQGDERLE YVSRITRYDP RESLRLDATA LRSLELFETR GTSTGHALVD
VLDDTSCALG RRELTSWLRR PLVDRERIEA RHDAVGEFAE HSLVREEVRD LLTDVYDLER
LIARVSRGRA NARDLRSLKT TLDVVPEVKS ALEDVESGKL RDLYDALDEL EDVRDLVGRA
VAEDPPIEIT EGGVIQSGFD DELDELRATE REGREWVADL EASEQERTGI DSLDVGYNQV
HGYYIEVTNP NLDQVPDDYQ RRQTLKNSER FYTPELKQRE DEILGAAERA DKLEYELFTE
VRSDIAAESD RVQALAAALA ELDVLATLAV VAVDNDYVRP EFHDGESDER GIHITGGRHP
VVERVQPTFV PNDTRLGGDA GDIAIITGPN MSGKSTYMRQ VALVVVLAQL GSFVPAESAT
LPVVDRVFTR VGASDDIAGG QSTFMREMSE LTDILHGATA DSLVLLDEVG RGTSTADGRA
IARATTEFID DEVGAYTLFA THYHELTAVA DEREGVFNLH FTASQDGDDV TFLHRVERGA
SSSSYGVEVA KMAGVPDRVV RRSQDLVDAE AAERGESGKP AASQLRANGH EVTQTTLPNG
SEAAVEADET QSAERSADAE TTPRDDVLAE IAAELDGIDV ARTTPLEALT RLNDLKRRLD
DRDS
//
