ID   A0A1G9YLR6_9ACTN        Unreviewed;       601 AA.
AC   A0A1G9YLR6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=3-oxosteroid 1-dehydrogenase {ECO:0000313|EMBL:SDN09445.1};
GN   ORFNames=SAMN04487981_103545 {ECO:0000313|EMBL:SDN09445.1};
OS   Streptomyces sp. cf386.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1761904 {ECO:0000313|EMBL:SDN09445.1, ECO:0000313|Proteomes:UP000198720};
RN   [1] {ECO:0000313|Proteomes:UP000198720}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF386 {ECO:0000313|Proteomes:UP000198720};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; FNHV01000003; SDN09445.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G9YLR6; -.
DR   STRING; 1761904.SAMN04487981_103545; -.
DR   Proteomes; UP000198720; Unassembled WGS sequence.
DR   GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR   GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   InterPro; IPR006311; TAT_signal.
DR   PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198720}.
FT   DOMAIN          58..583
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
SQ   SEQUENCE   601 AA;  62253 MW;  BCFFFFAE73108C8C CRC64;
     MVRAGAAIMT TTTTTDARPS RRGVLAAGAA TTAAAFGVVG AAQQTARAAD LPLLGTYDVV
     VIGSGAAGMT AALTAAKQGL SCVVLEKAPT FGGSAARSGA GIWIPDNSVI LAAGVPDTPA
     KAAAYLAAVV GPDVPADRQR AFLTHGPAML SFVMANSPLR FRWMEGYSDY YPELPGGLPN
     GRSIEPGQLD GNLLGAELAR LNPPYMDVPA GMVVFSADYK WLALAAVNAK GAAVAAECLA
     RGTAAALRGE KPLTMGQSLA AGLRLGLRSA GVPVWLGTPL TDLYVEGGAV SGAVVTRDGA
     PALVRARRGV IVGSGGFEHN AAMRATYQRG PIGTDWTVGA KENTGDGIRA GHRLGAALGL
     MDDAWWGPAI PLPGQPYFCL AERTLPGGLL INAAGARFVN EAAPYSDVVH TMYDVNDTDP
     AIPSWLIVDQ HYRNRYLFKD VLPTLPLPDA WYGSGAAHKA WTLDGLARSI GVPATALRTT
     VDRFNSQALR GEDPDFHRGD SAYDHYYTDP SVLPNSCLAP LWLPPYHAFR IVPGDLGTKG
     GLLTDARARV LREDGSVIPG LYAAGNASAA VMGHSYAGAG STIGPAMTFG YIAARDIAGN
     P
//