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Database: UniProt
Entry: A0A1G9Z395_9EURY
LinkDB: A0A1G9Z395_9EURY
Original site: A0A1G9Z395_9EURY 
ID   A0A1G9Z395_9EURY        Unreviewed;       754 AA.
AC   A0A1G9Z395;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Allosteric NADP-dependent malic enzyme {ECO:0000313|EMBL:SDN15251.1};
GN   ORFNames=SAMN05192554_11758 {ECO:0000313|EMBL:SDN15251.1};
OS   Haloarchaeobius iranensis.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halorubellaceae; Haloarchaeobius.
OX   NCBI_TaxID=996166 {ECO:0000313|EMBL:SDN15251.1, ECO:0000313|Proteomes:UP000199370};
RN   [1] {ECO:0000313|EMBL:SDN15251.1, ECO:0000313|Proteomes:UP000199370}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EB21,IBRC-M 10013,KCTC 4048
RC   {ECO:0000313|Proteomes:UP000199370};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the malic enzymes
CC       family. {ECO:0000256|ARBA:ARBA00007686}.
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DR   EMBL; FNIA01000017; SDN15251.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G9Z395; -.
DR   STRING; 996166.SAMN05192554_11758; -.
DR   OrthoDB; 45556at2157; -.
DR   Proteomes; UP000199370; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR   Gene3D; 3.40.50.10950; -; 1.
DR   Gene3D; 3.40.50.10750; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR   InterPro; IPR012188; ME_PTA.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR042113; P_AcTrfase_dom1.
DR   InterPro; IPR042112; P_AcTrfase_dom2.
DR   InterPro; IPR002505; PTA_PTB.
DR   PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR   PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   Pfam; PF01515; PTA_PTB; 1.
DR   PIRSF; PIRSF036684; ME_PTA; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199370}.
FT   DOMAIN          16..149
FT                   /note="Malic enzyme N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01274"
FT   DOMAIN          161..401
FT                   /note="Malic enzyme NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00919"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   754 AA;  81879 MW;  B39DD698C23379F6 CRC64;
     MGLDEDSLDY HEADPPGKLE ISTTKPTNTQ RDLSLAYSPG VAEPCRRIAD DPDDAYRYTA
     KGNLVGVVSN GSAVLGLGDI GAQASKPVME GKGVLFKRFA DIDVFDVELD QDDPEKIIEA
     VSAMEPTFGG INLEDISAPE CFTIEETLRE EMDIPVFHDD QHGTAIISGA ALLNAAEIAG
     KDLEDLEIVF SGAGASALAT ARFYVSLGAK RENITMCDSS GIITTARAES GDVNEYKQEF
     ARDIDGGGLA DAMADSDVFV GLSIGGLVDQ EMVRSMADNP IVFAMANPDP EIGYEEAKAA
     RDDTVIMATG RSDYPNQVNN VLGFPFIFRG ALDVRATEIN EEMKVAAASA LAELSKQDVP
     DAVVKAYGDQ PLQFGPDYII PKPLDPRVLF EVAPAVAEAA MDSGCARQEL DLEAYEERLE
     ARLGKSREMM RVVLNKAKSD PKRIALAEGA DEKMIRAAYQ LEEQGIAEPI LIGNDDRITK
     TTERLGLDFE PTIANPRADD ERHEDYAERL YQVRKRKGLT KSEAEDLIRR DTNYYGSVMV
     ECGDADALLT GLTHHYPSAL RPPLQVIGTA EEADFAAGVY MLTFKNRVIF CADTTVNQDP
     DAKVLAEVAD HTAELARRFN VDPRVAMLSY SNFGSVDNAG TRKPRRAADM LRNDDGIDYP
     VDGEMQADTA VVEEILRGTY EFSDLEDPAN VLVFPNLEAG NIGYKLLQRL GGAEAIGPML
     VGMDKPVHVL QRGDEVKDIV NLAGVAVVDA QQNE
//
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