ID   A0A1G9Z8Y8_9ACTN        Unreviewed;       265 AA.
AC   A0A1G9Z8Y8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=NAD-dependent protein deacetylase, SIR2 family {ECO:0000313|EMBL:SDN17291.1};
GN   ORFNames=SAMN05192576_1638 {ECO:0000313|EMBL:SDN17291.1};
OS   Nocardioides szechwanensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=1005944 {ECO:0000313|EMBL:SDN17291.1, ECO:0000313|Proteomes:UP000199004};
RN   [1] {ECO:0000313|EMBL:SDN17291.1, ECO:0000313|Proteomes:UP000199004}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.11147 {ECO:0000313|EMBL:SDN17291.1,
RC   ECO:0000313|Proteomes:UP000199004};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNIC01000002; SDN17291.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G9Z8Y8; -.
DR   STRING; 1005944.SAMN05192576_1638; -.
DR   OrthoDB; 9800582at2; -.
DR   Proteomes; UP000199004; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR11085:SF2; NAD-DEPENDENT PROTEIN LIPOAMIDASE SIRTUIN-4, MITOCHONDRIAL; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00236}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199004};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00236}.
FT   DOMAIN          1..265
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   ACT_SITE        108
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         116
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         119
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         167
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         170
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ   SEQUENCE   265 AA;  27939 MW;  950F15ECCA17503C CRC64;
     MTDALDLLRS RPLVVLTGAG LSTDSGIPDY RGPGSPARAP MTYQEFVATP DARQRYWARS
     HLGWGRMRHA APNDGHRALA ALDPELLITQ NVDGLHEAAG SRRLVALHGR IADVVCLGCR
     ETSSRVSLHE RLTALNPGFA SRHAAAEVRP DGDVDLDDTA GFVVPSCGGC GGVLKPDVVF
     FGENVPAPRV ERCYAAVDGL ASSGGALLVA GSSLTVMSGF RFVRRAARAG VPVVIVNRGV
     TRGDDHATYK LDVGCSEFLS ELAAA
//