ID   A0A1G9ZZG1_9FIRM        Unreviewed;      1264 AA.
AC   A0A1G9ZZG1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=SAMN05660299_02428 {ECO:0000313|EMBL:SDN26668.1};
OS   Megasphaera paucivorans.
OC   Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC   Megasphaera.
OX   NCBI_TaxID=349095 {ECO:0000313|EMBL:SDN26668.1, ECO:0000313|Proteomes:UP000199309};
RN   [1] {ECO:0000313|EMBL:SDN26668.1, ECO:0000313|Proteomes:UP000199309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16981 {ECO:0000313|EMBL:SDN26668.1,
RC   ECO:0000313|Proteomes:UP000199309};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; FNHQ01000034; SDN26668.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G9ZZG1; -.
DR   STRING; 349095.SAMN05660299_02428; -.
DR   OrthoDB; 32195at2; -.
DR   Proteomes; UP000199309; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR047939; BREX_1_PglX.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SDN26668.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199309};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          496..641
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
FT   COILED          1205..1232
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1264 AA;  146176 MW;  595E5276AD40218D CRC64;
     MDKAAIKKFA VWARNKLIKD ISYKAGLMGI TEDGIAEKLP QSATDAEFYD IGLKQPHVIS
     GEAIQQRNCL ADLIQQTMAG SDYQVAYYSV IEEVAYTWFN RLIAVRFMEV NDYLPSHIRV
     LSSDNAAKLE PDIVTTPFDA GLSFTQTEQE KILCLKNDNK VDALFRLLFI KQCNALHSLL
     PNLFEKTEDY SELLLNVSVT DPDGVVYHLV HDINEDDFNV AKGGQVEIIG WLYQYYNDER
     KNEVINIYKG TVKKEDIPAA TQLFTTDWVV RYIVDNSLGR YWIERHPNSH LKDKLQYLVI
     PKDQSICYID DKIIPENLLI LDPCMGSGHF LIYTFEVLIK IYEECGYSAK DAAKVILEHN
     LYGLDIDDRA FQLAYFAVMM KARQYNRRIL NENVVCHVYS IQESNVINRN QWEFFGTRLN
     DSERNVAIEQ MNKLLDIFID AKEYGSLLSI EDDYNWNLLR KFAVVDNEKD QMQLDFMGLK
     PMQEQLQKII DIGQAMAQKY EIVVTNPPYL NKMDVKLKDF VNDQYKKYSG DLFSAFIYRN
     LNFCKYNGYS GFMTPFVWMF IKTYEKLREF IIQNKSITTL VQMEYSAFEE ATVPICTFVL
     KNGKSNDKGL YIKLSNFKGG MDVQREKVLE AITNKNCNYF FESLQSNFSK IPGSPIAYWV
     SKNVLSAYDY GKQLGKLAFP KTGMTTGDNN RFLRLWPEIK FIKISLNSKD MNDSVLSKKK
     WFPYCKGGGF KRWYGYNEYL VNWENNGFEI KSNIKSNGIK VASVRSEALY FKQLITWSAV
     TSGKFSCRLC LGGALFDSGG SSIIVNANQL YLLALLNSVV GQYYLNITNA TINYQPGDIA
     GIPILFQNEH EIEELTKQCI KLAKQDWNSF ETSWDFLVHP LVKYRDYSVN IENREVISRE
     CLGLVNSFKT WQTICNNQFD TLKTNEEELN RIFIEIYGLQ DALTPDVADK DVTVARIYDT
     KEDISEFMKG NRYILTKQDV IKSLISYAVG CMFGRYSLDK EGLVFAGGNF DQTYWKYKGQ
     AALNENGEPI AGGYANISMA RYHYPAFRDS DNWRTATKLT FEPDVDNIIP ITDEAYFEDD
     IVGLFCTWLK KVYGEDTLEE NLSFIAQALG YRGNTNREVI RNYFLKDFFN DHCKTYKKRP
     IYWLFDSGKN NGFKALIYMH RYDENTIGNV RIDYLHRIEQ IYEGEIKRMQ DTIDNSTDAH
     EFTATEKQKE KLQKQQNECK EYDEKIAHLA LARISIDLDD GVKVNYEKVQ TGKDGKQYQI
     LAKI
//