ID   A0A1H0AGH6_9FIRM        Unreviewed;       257 AA.
AC   A0A1H0AGH6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   ORFNames=SAMN05192585_11624 {ECO:0000313|EMBL:SDN32722.1};
OS   Acetanaerobacterium elongatum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Acetanaerobacterium.
OX   NCBI_TaxID=258515 {ECO:0000313|EMBL:SDN32722.1, ECO:0000313|Proteomes:UP000199182};
RN   [1] {ECO:0000313|EMBL:SDN32722.1, ECO:0000313|Proteomes:UP000199182}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.5012 {ECO:0000313|EMBL:SDN32722.1,
RC   ECO:0000313|Proteomes:UP000199182};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000256|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
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DR   EMBL; FNID01000016; SDN32722.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0AGH6; -.
DR   STRING; 258515.SAMN05192585_11624; -.
DR   OrthoDB; 9795084at2; -.
DR   Proteomes; UP000199182; Unassembled WGS sequence.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   NCBIfam; TIGR02772; Ku_bact; 1.
DR   PANTHER; PTHR41251; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR   PANTHER; PTHR41251:SF1; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SPOC domain-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_01875}; Reference proteome {ECO:0000313|Proteomes:UP000199182}.
FT   DOMAIN          52..180
FT                   /note="Ku"
FT                   /evidence="ECO:0000259|SMART:SM00559"
SQ   SEQUENCE   257 AA;  28897 MW;  C4A350E836140759 CRC64;
     MPVSHKSAIS FGLVHIPVAL YTATQDNDIS FNQLHKEDNQ RVRYKKVCGH CGKEVAFGDI
     IKGFEYDKDK YVVVTDEDFE TIKTEKDKTI QILHFANLNQ ISPVYYDKTY QAIPEAGGEK
     AFELLRAAMM AEQKIAIGKT VMGTKETLLA IIPREDGILI ETMFYADEIK ELQKPYTRPP
     VNEAELDMAK KLIASMDTEF SPSKHKDEYQ VRLRALIEQK IAGKEIIAAT PKPQNNVIDL
     MEALKASLEQ GTKGKGA
//