ID   A0A1H0AKG3_9FIRM        Unreviewed;       575 AA.
AC   A0A1H0AKG3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Dihydroxy-acid dehydratase {ECO:0000313|EMBL:SDN33316.1};
GN   ORFNames=SAMN05660299_02533 {ECO:0000313|EMBL:SDN33316.1};
OS   Megasphaera paucivorans.
OC   Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC   Megasphaera.
OX   NCBI_TaxID=349095 {ECO:0000313|EMBL:SDN33316.1, ECO:0000313|Proteomes:UP000199309};
RN   [1] {ECO:0000313|EMBL:SDN33316.1, ECO:0000313|Proteomes:UP000199309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16981 {ECO:0000313|EMBL:SDN33316.1,
RC   ECO:0000313|Proteomes:UP000199309};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC       {ECO:0000256|ARBA:ARBA00006486}.
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DR   EMBL; FNHQ01000039; SDN33316.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0AKG3; -.
DR   STRING; 349095.SAMN05660299_02533; -.
DR   Proteomes; UP000199309; Unassembled WGS sequence.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0016836; F:hydro-lyase activity; IEA:InterPro.
DR   GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.30.80; IlvD/EDD C-terminal domain-like; 1.
DR   InterPro; IPR042096; Dihydro-acid_dehy_C.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   InterPro; IPR037237; IlvD/EDD_N.
DR   PANTHER; PTHR43661; D-XYLONATE DEHYDRATASE; 1.
DR   PANTHER; PTHR43661:SF3; D-XYLONATE DEHYDRATASE YAGF-RELATED; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF143975; IlvD/EDD N-terminal domain-like; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
PE   3: Inferred from homology;
KW   2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022714};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199309}.
SQ   SEQUENCE   575 AA;  62171 MW;  CF717E869F1F8778 CRC64;
     MIEQKSKQTR KIWPQVDALK LAMNWSEKDL DKLQILVDDV QGESHPGSYH LDTLSKESCV
     GVFESGGRPA KFHVTDICDG WAEGHDGMNY ILPSREVIAN MVEIHGNVIP WDGLILLSGC
     DKAVPAHLIA AARLDLPTVH IPSGSQHSGP NLTTAGLCGR LTAKDKRGEA TAAEMRNYKL
     TGCPTCGVCQ FMGTASTMQC MSEALGLALP GTALMPAMFG EIKHYARAAG LAVMNLAEKG
     ITASKILTKE AFINAIKVHA ALGGSTNAFI HLPAVAHELG ITIEPDIFDE INRKVKHLVN
     VQPNGKYVGE LFWMAGGVPM VEWLIRDCLD LDVMTCTGKT LGENLEQLWE DDYFVRCQGH
     LQTFGINPED VITPPEKATM YGSVAVMRGN IAPDGSVIKY SATVSSMQHH IGKAAVFDSE
     EAAYDAVIKR HIQPDTVVVI RYEGPKGSGM PEMHMTTDAI IYDDTLNKSV AVVTDGRFSG
     ASSGPCIGHV SPEAVEGGPI ALIENDDLIE IDIPNRALNI VGVAGVHKTP DEISEIMINR
     KKNWKLPTLK PKKGILKIYT KLAVSGMAGA YMDID
//