ID A0A1H0ASR1_9ACTN Unreviewed; 384 AA.
AC A0A1H0ASR1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Uroporphyrinogen-III synthase {ECO:0000313|EMBL:SDN36552.1};
GN ORFNames=SAMN05444921_12532 {ECO:0000313|EMBL:SDN36552.1};
OS Streptomyces wuyuanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1196353 {ECO:0000313|EMBL:SDN36552.1, ECO:0000313|Proteomes:UP000199063};
RN [1] {ECO:0000313|Proteomes:UP000199063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7042 {ECO:0000313|Proteomes:UP000199063};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNHI01000025; SDN36552.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0ASR1; -.
DR STRING; 1196353.SAMN05444921_12532; -.
DR OrthoDB; 213853at2; -.
DR Proteomes; UP000199063; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR039793; UROS/Hem4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Reference proteome {ECO:0000313|Proteomes:UP000199063}.
FT DOMAIN 280..373
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 280..373
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 384 AA; 40670 MW; 10CBB3E02ECCD39D CRC64;
MYHEQHGAPA VAPLAGFTVG VTAARRADEL GALLQRRGAA VLHAPALRIV PLADDGELLA
ATKELIDNPP DVVVATTAIG FRGWVEAADG WGFGEELLAC LRGVELLARG PKVKGAIRAA
GLTEEWSPTS ESMAEVLDRL LGEGVADRRV ALQLHGEPLP GFVEALRVGG AEVVVVPVYR
WMPPEDLAPL DRLLDAAVGR SLDAVTFTSA PAAASLFSRA EDRGMLPELL DALAHDVLPA
CVGPVTALPL QAVGLDTVQP DRFRLGPLVQ LLCVELPSRA RTLPVAGRRV EIRGHAVLVD
GEVRPVPPAG MSLLNTLARR PGWVVSRADL LRALPGAGRD EHAVETAMAR LRTALGVPNL
IQTVVKRGYR LALDPAVDTK YADT
//
