ID A0A1H0AU71_9ACTN Unreviewed; 728 AA.
AC A0A1H0AU71;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SAMN05444921_12550 {ECO:0000313|EMBL:SDN36885.1};
OS Streptomyces wuyuanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1196353 {ECO:0000313|EMBL:SDN36885.1, ECO:0000313|Proteomes:UP000199063};
RN [1] {ECO:0000313|Proteomes:UP000199063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7042 {ECO:0000313|Proteomes:UP000199063};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; FNHI01000025; SDN36885.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0AU71; -.
DR STRING; 1196353.SAMN05444921_12550; -.
DR OrthoDB; 9762169at2; -.
DR Proteomes; UP000199063; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF6; SERINE_THREONINE-PROTEIN KINASE NEKL-3; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:SDN36885.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000199063};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:SDN36885.1};
KW Transferase {ECO:0000313|EMBL:SDN36885.1}.
FT DOMAIN 16..268
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 301..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 728 AA; 77034 MW; 0C28685CA5C69949 CRC64;
MLSPLTHDDP ELLARYRLQA RLGSGGMGTV YLARTPGGRT VALKTMHQAI AADPAARTRF
RLETDAARII GSQHGAAVVD ADPLAETPWL ATEYVLGPPL DDAVELCGPL PESGVRALGA
ALAGALGQLH SSDVVHRDLK PSNVMITAYG PKIIDFGIAR ADGDERLTRV GVAAGTPAFM
SPEQATGQDH TPAGDVFALA GVLVYAASGH GPFGTGQAAD LLYRVRYAEP DLTGVPAALV
PVLSRCLAKQ SGERPTTAQL VGELHDGRGD FADHLPDTVL MEIARRATEV WQYTPYRLPA
PTGAPLPRTV PDSGSRSRTS RRRLLGLSGA SALAVACAGA GAWAWLRDPD AGTTGGAGGR
GATPPPVTGP TVEGQAWLKN VIPAKADTAA LLAPLPVGEV AVLATGEGLL GLAALNGERR
WLVRDVRESR HVHTDGKQIH VLLREEPHRS RAVLHTVDPR DGRLSPPVVF KPLVRRVALL
RVGGGTAYVA AEEPGGFLWH LRALDARTGQ EKWSTPLRAA DVGGPDDLVV TALAVGRLIL
HRPASGGSGH EVSALDVRNG RQLWRTTLPG EKHGIPSLAP NSLVTDDRHV YVGGQRLQAL
RLTDGKAAWT FGAGRPAGAY GTPALRDGIV HAAERDKGVV AVAAADGRLR WEAETGGRPD
LTVPVVVNDR FVYVMTGGSV YSVGRESKRQ EWVFRRRSRT MSLHERVPRL VLTDGTDVAA
VNLAFDYG
//