ID A0A1H0BR34_9ACTN Unreviewed; 777 AA.
AC A0A1H0BR34;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=ATPase, P-type (Transporting), HAD superfamily, subfamily IC/heavy metal translocating P-type ATPase {ECO:0000313|EMBL:SDN48055.1};
GN ORFNames=SAMN04487981_105196 {ECO:0000313|EMBL:SDN48055.1};
OS Streptomyces sp. cf386.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761904 {ECO:0000313|EMBL:SDN48055.1, ECO:0000313|Proteomes:UP000198720};
RN [1] {ECO:0000313|Proteomes:UP000198720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF386 {ECO:0000313|Proteomes:UP000198720};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
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DR EMBL; FNHV01000005; SDN48055.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0BR34; -.
DR STRING; 1761904.SAMN04487981_105196; -.
DR OrthoDB; 7059309at2; -.
DR Proteomes; UP000198720; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd12108; Hr-like; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 1.20.120.520; nmb1532 protein domain like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR012312; Hemerythrin-like.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR48085; CADMIUM/ZINC-TRANSPORTING ATPASE HMA2-RELATED; 1.
DR PANTHER; PTHR48085:SF5; CADMIUM_ZINC-TRANSPORTING ATPASE HMA2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF01814; Hemerythrin; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000198720};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 26..45
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 52..70
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 82..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 272..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 579..598
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 639..775
FT /note="Hemerythrin-like"
FT /evidence="ECO:0000259|Pfam:PF01814"
FT REGION 386..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 81049 MW; 398F592D75C1265C CRC64;
MNRFLPGRPS HRLLTALSRM PPLESLLLAD TVVALTVGGA FWLAGATGLA ELCWALGTVV
AVGPAIGWVL GALRRGQAGV DLIAVLALGG TLAVGEYLAG SLIALMLATG RALEASARQR
ASRDLRALLE HAPRTARRRT GTDVREVPLA VVAVGDLLVV GPGEVVPVDG SVAGDPAELD
ESVLTGEPLA VRHPPGESVR SGAVNAGGAF ELRATATAQD STYAGIVRLA RQASAESAPV
VRLADRYAAW FLPLTVAVAG LTWLISGSAV RAVAVLVVAT PCPLLLAAPV AVVSGLSRAS
RLGVVIRDGG ALENLGRART LLLDKTGTLT GGHPRVLDVI AAHGWQPSQV LRLAASLDQY
SPHVLARALV DAARERGLRL SVPADVSEEP GRGARGTIAG RRMGVGGLDT DAEKPAWARS
ADNRAVLDGA TVVWLTVDSR PVGAVLLRDA LRHDAPRTLR RLRSAGVERL VMLTGDRPEP
AHEVGAVLGL DDVRAGLSPA GKVTAVRAER DRAVTVMVGD GVNDAPALAA ADVGVAMGAR
GSTASSETAD IVLTTDRVDR LADAVGIAVR SRRIAVQSAL GGMALSLIAM AAAALGFLPP
AVGALLQEGI DVAVILNALR ALGDDRRARP TLQPSTEALI HRFAREHDDL QDVLEAVRSA
ADHLSDSPGP QALAAVRHVH HLLTERLLPH EYAEEHQLYP ALAPTLGGPE ATATMSRAHV
EIDRLAHRIA THLALAGPEG ILAPEQLDDL RACLYGLHTV LRLHFTQEEE NYFSLAP
//
