ID   A0A1H0C6Z4_9FIRM        Unreviewed;       533 AA.
AC   A0A1H0C6Z4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Fructuronate reductase {ECO:0000313|EMBL:SDN53611.1};
GN   ORFNames=SAMN05192585_12210 {ECO:0000313|EMBL:SDN53611.1};
OS   Acetanaerobacterium elongatum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Acetanaerobacterium.
OX   NCBI_TaxID=258515 {ECO:0000313|EMBL:SDN53611.1, ECO:0000313|Proteomes:UP000199182};
RN   [1] {ECO:0000313|EMBL:SDN53611.1, ECO:0000313|Proteomes:UP000199182}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.5012 {ECO:0000313|EMBL:SDN53611.1,
RC   ECO:0000313|Proteomes:UP000199182};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate
CC         + H(+) + NADH; Xref=Rhea:RHEA:19661, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57634, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:61381; EC=1.1.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00000292};
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DR   EMBL; FNID01000022; SDN53611.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0C6Z4; -.
DR   STRING; 258515.SAMN05192585_12210; -.
DR   OrthoDB; 271711at2; -.
DR   Proteomes; UP000199182; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43362:SF1; MANNITOL DEHYDROGENASE 2-RELATED; 1.
DR   PANTHER; PTHR43362; MANNITOL DEHYDROGENASE DSF1-RELATED; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199182}.
FT   DOMAIN          39..197
FT                   /note="Mannitol dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01232"
FT   DOMAIN          235..471
FT                   /note="Mannitol dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08125"
SQ   SEQUENCE   533 AA;  58511 MW;  4F5DC34C12337E5B CRC64;
     MNLNYEGIRD SEAWQEAKVR LPRYDVQAVA KATKEHPVWL HFGAGNIFRG FIAALQDRLL
     NEGLANKGIV AVESFDYDII KEVYAPHDNL TLLVTLKADG NNEKSVVASI AAGFTTADDF
     AILQGYFKDV QLRMVSFTIT EKGYSLFDMS GNLLPVADAD MKNGPQKPVH VMAVLTSLLY
     TRYKNGMAPI ALVSMDNCSH NGEKLANAVK TVAAAWEQAG FVDKGFLAYI GDEKRVSFPW
     SMIDKITPRP DGEIYKALTE SGIEGMAPIV TGKGTYIAPF VNAEAPQYLV VEDSFPAGRP
     MLEKAGVYFT SRDTVNRMER MKVTTCLNPL HTALAVFGCL LGYTKISEEM KDEQLSKLVR
     RIGYVEGLPV VTHPGILEPR AFLDEVVNER LPNPYIPDTP QRIACDTSQK IPIRFGETIK
     AYLASPEWNT DCLTGISLAL AGWLRYLLGV DDELNPMTVS SDPLLNELQA ALAGIEVGDP
     QSAEGKLDGI LHNAALFGVD LFEAGLADRV QMLFECMLQG KGAVRALLKD YIG
//