ID   A0A1H0CYP4_9GAMM        Unreviewed;       296 AA.
AC   A0A1H0CYP4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:SDN62751.1};
GN   ORFNames=SAMN04487957_101192 {ECO:0000313|EMBL:SDN62751.1};
OS   Halomonas shengliensis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=419597 {ECO:0000313|EMBL:SDN62751.1, ECO:0000313|Proteomes:UP000199075};
RN   [1] {ECO:0000313|Proteomes:UP000199075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.6444 {ECO:0000313|Proteomes:UP000199075};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080}.
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DR   EMBL; FNIV01000001; SDN62751.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0CYP4; -.
DR   STRING; 419597.SAMN04487957_101192; -.
DR   OrthoDB; 9786703at2; -.
DR   Proteomes; UP000199075; Unassembled WGS sequence.
DR   GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006398; Tartro_sem_red.
DR   NCBIfam; TIGR01505; tartro_sem_red; 1.
DR   PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          3..162
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          165..285
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        171
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   296 AA;  30797 MW;  5E3DC4FE9F7955D0 CRC64;
     MSKIGFIGLG IMGRPMAGHL LDAGHELTTV KRGKPLASEL ADKGMQELAS PRAVAEQAEV
     IITMVPDTPD VEQVLFGEQG VIEGLKPGTL VIDMSSIAPI PTQDFARRIH EAGGEYVDAP
     VSGGEGGAIN AALTIMVGAT DEGFTRARPV LEVMGKTITH IGGHGAGQTC KVANQIVVAL
     TIEAVAEGLL FASKAGADVA KVRESLLGGL AQSKILDVHG ERMIQRTFDP GFKIKLHQKD
     LNLALEGARS LDLALPGTAN AQQLFQACAA NGGAEWDHAG ILRALETLAN HAVGQA
//