ID   A0A1H0DI37_9GAMM        Unreviewed;       294 AA.
AC   A0A1H0DI37;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:SDN69800.1};
GN   ORFNames=SAMN04487957_101424 {ECO:0000313|EMBL:SDN69800.1};
OS   Halomonas shengliensis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=419597 {ECO:0000313|EMBL:SDN69800.1, ECO:0000313|Proteomes:UP000199075};
RN   [1] {ECO:0000313|Proteomes:UP000199075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.6444 {ECO:0000313|Proteomes:UP000199075};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNIV01000001; SDN69800.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0DI37; -.
DR   STRING; 419597.SAMN04487957_101424; -.
DR   OrthoDB; 9772407at2; -.
DR   Proteomes; UP000199075; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd19138; AKR_YeaE; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE   4: Predicted;
FT   DOMAIN          23..280
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        61
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         119
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            86
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   294 AA;  31981 MW;  ED88D4D343B7C0C5 CRC64;
     MLPAPRVTLP ATTHEPAVAL PTIGQGTWYM GEGRAPRRDE VRALQHGLAM GLTLIDTAEM
     YADGGAEQVV GEALAGRRDE AFLVSKVYPW NAGRESAIAA CEASLRRLRT DHLDLYLLHW
     PGDIPLEETL EAFERLREAG KIRRFGVSNF DVDELAALHG LPSGDACAVN QVLYHLGSRG
     IEHSLLPWQR QRGMPTMAYC PLAQAGGLRE DLLGHPEVTG IAARHGITSA QVLLAWAIRP
     VEGRRDVIAI PKAARTEHVE QNAAALQVRL DDDALARLEA AFPAPARKVA LDIV
//