ID   A0A1H0DQ78_9BACT        Unreviewed;       638 AA.
AC   A0A1H0DQ78;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 11.
DE   SubName: Full=NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC {ECO:0000313|EMBL:SDN72397.1};
GN   ORFNames=SAMN04487900_102123 {ECO:0000313|EMBL:SDN72397.1};
OS   Prevotella communis.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=2913614 {ECO:0000313|EMBL:SDN72397.1, ECO:0000313|Proteomes:UP000199134};
RN   [1] {ECO:0000313|Proteomes:UP000199134}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BP1-145 {ECO:0000313|Proteomes:UP000199134};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:SDN72397.1}.
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DR   EMBL; FNIW01000002; SDN72397.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0DQ78; -.
DR   OrthoDB; 9803111at2; -.
DR   Proteomes; UP000199134; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        94..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        125..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          306..586
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
SQ   SEQUENCE   638 AA;  72315 MW;  82C1EE21EEBDDF10 CRC64;
     MKNPLDKIIS WYFTKNTLPY WCVLIADSLF VFLSGIFTFW TFRKTAVLFD FRFAVLYTML
     IYTAFAIIGF RVFRTYSGIV RYSSFVDLMR VGYGSLLSMV IALIYSVIAE KYVCCIAILS
     QTETVVTFCV ATLLMWAGRV MVKNLYDVMV SDKRAMRVLI YGALSGGIGL AKYINSQNPK
     KYLLQGFISH DKQAKHMLLM GKQVYNVNDN LEDIIAQKHI DAVLVSPLRI DDFRNNQQIQ
     DMLIKAGCKI YMAQQAKELK PNEDNLNEDN FRSMQLKEVS VEDLLPRQEI VVDMESVGAL
     LKGKRVLITG SAGSIGSEMV RQVAVYKPAK MMLIDQAETP EHDIRLMMEK EFPDVKAETV
     VTSICKEDRM EQIFSDFKPD YVFHAAAYKH VPMMENNPSE AVQNNIYGTK VIADLSVKYG
     VKKFVMVSTD KAVNPTNVMG CSKRICEIYV QSLGKTTDKT QFITTRFGNV LGSNGSVIPL
     FREQIKNGGP VTVTDPRIVR FFMLIPEACK LVLEAGTKGH GGEIFVFDMG QPVKIADLAQ
     RMIALSGAKN VKIEYTGLRA GEKLYEEVLN ELEGTKPSFH EKIRIAEVRE YDYEEVNKEI
     NNLIAISKQY DDMATVKKMK EIVPEYKSNN SVYEVLDK
//