ID A0A1H0EVK9_9GAMM Unreviewed; 484 AA.
AC A0A1H0EVK9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Cobyric acid synthase {ECO:0000256|ARBA:ARBA00019833, ECO:0000256|HAMAP-Rule:MF_00028};
GN Name=cobQ {ECO:0000256|HAMAP-Rule:MF_00028};
GN ORFNames=SAMN04487951_10920 {ECO:0000313|EMBL:SDN86424.1};
OS Halomonas arcis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=416873 {ECO:0000313|EMBL:SDN86424.1, ECO:0000313|Proteomes:UP000199677};
RN [1] {ECO:0000313|Proteomes:UP000199677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.6494 {ECO:0000313|Proteomes:UP000199677};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes amidations at positions B, D, E, and G on
CC adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine,
CC and one molecule of ATP is hydrogenolyzed for each amidation.
CC {ECO:0000256|ARBA:ARBA00025166, ECO:0000256|HAMAP-Rule:MF_00028}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953, ECO:0000256|HAMAP-Rule:MF_00028}.
CC -!- SIMILARITY: Belongs to the CobB/CobQ family. CobQ subfamily.
CC {ECO:0000256|ARBA:ARBA00006205, ECO:0000256|HAMAP-Rule:MF_00028}.
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DR EMBL; FNII01000009; SDN86424.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0EVK9; -.
DR STRING; 416873.SAMN04487951_10920; -.
DR OrthoDB; 9808302at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000199677; Unassembled WGS sequence.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd05389; CobQ_N; 1.
DR CDD; cd01750; GATase1_CobQ; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00028; CobQ; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002586; CobQ/CobB/MinD/ParA_Nub-bd_dom.
DR InterPro; IPR033949; CobQ_GATase1.
DR InterPro; IPR047045; CobQ_N.
DR InterPro; IPR004459; CobQ_synth.
DR InterPro; IPR011698; GATase_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00313; cobQ; 1.
DR PANTHER; PTHR21343:SF1; COBYRIC ACID SYNTHASE; 1.
DR PANTHER; PTHR21343; DETHIOBIOTIN SYNTHETASE; 1.
DR Pfam; PF01656; CbiA; 1.
DR Pfam; PF07685; GATase_3; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51274; GATASE_COBBQ; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573, ECO:0000256|HAMAP-
KW Rule:MF_00028};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|HAMAP-Rule:MF_00028};
KW Reference proteome {ECO:0000313|Proteomes:UP000199677}.
FT DOMAIN 4..229
FT /note="CobQ/CobB/MinD/ParA nucleotide binding"
FT /evidence="ECO:0000259|Pfam:PF01656"
FT DOMAIN 250..432
FT /note="CobB/CobQ-like glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF07685"
FT ACT_SITE 329
FT /note="Nucleophile"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00028"
FT ACT_SITE 426
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00028"
SQ SEQUENCE 484 AA; 51792 MW; 14A8B07CA5F6954C CRC64;
MTTLMIQGTT SDAGKSTVVA GLCRVLQRRG LSVAPFKPQN MALNSAVTVD GGEIGRSTAL
QAQAAGVEPH SDMNPVLLKP ETDRGAQVIL RGKVYGHMDA IDYHAFKRTA QDSVMAAWEA
LESRFDVVIA EGAGSPAEVN LREGDIANMG FAEAADCPVL LVGDIDRGGV FAQLVGTLAL
LSESEQARTR GFIINRFRGD IGLLNPGLEW LTTRTGKPVL GTLPYLQGLL LDAEDSIGLT
HAEKVSQTLK VVVPALPRIS NHTDFDPLRL HPQVALTFVG PDQPIPPADV IILPGSKSTV
SDLAWLKRQG WDKAIQRHLR YDGKVLGICG GFQMLGEWVN DPDGLEGKPG KIAGLGLLPL
TTRMVAGKQL RNVSGVTVAE GATVTGYEIH NGVSHGPALT SPLFDLGSHL DGAVSDDGQV
MGTYLHGLFD HPDACQALLM RLGLEAAYSV DYRAHREREL NRLAETLETH LDIEAIIALL
RADV
//