ID A0A1H0F221_9ACTN Unreviewed; 547 AA.
AC A0A1H0F221;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=SAMN04487981_107169 {ECO:0000313|EMBL:SDN88596.1};
OS Streptomyces sp. cf386.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761904 {ECO:0000313|EMBL:SDN88596.1, ECO:0000313|Proteomes:UP000198720};
RN [1] {ECO:0000313|Proteomes:UP000198720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF386 {ECO:0000313|Proteomes:UP000198720};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNHV01000007; SDN88596.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0F221; -.
DR STRING; 1761904.SAMN04487981_107169; -.
DR Proteomes; UP000198720; Unassembled WGS sequence.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000198720}.
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..80
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 60288 MW; 7D25788CECA9BD34 CRC64;
MTPQPNPHTA PGHADLLAAP GHAGSHAALS DSGPHGGPHP GGHTSHEDSH TSPHTGPRTN
PDPRLHSGPH PTPQPGPDPE PDPDTPRDLV GIGIGPFNLS LAALAHPLAE LDAVFYERRT
AFSWHPGLLI DGARIQVPFL ADLVTLVDPA SPWSFLNYLK ARDRLFPFYF AERFHIQRAE
YDAYCRWVCE NLPGLSFGHQ VDAVRFNPER DVFEVDFTQL GPDGEAEALG RTYARNIVLG
IGTEPYVPDP LRPLVEAPAV PVIHAADYMN HRDTLLAAEH VTVIGSGQSG AEVFLDLLRR
RPAGREGLHW LGRTAAFAPM EYSKLGLEHF TPDYTRYFHA LAEPVRDKLV ASQWQLHKGI
DADTLAAIHD ELYRRTLHGG WPEVVLTPGV RVRTGGRVAT TKVELHLEHV HQNTRSRLTT
DAVVLATGYR ERPFDCLLAG LDPYLRRDSQ ERPRIDDQHR LVMDPHVTGS GCNVYVQNAE
RHTHGIGTPD LGLAAWRSAG ILNAVTGKET YPLPTRTAFT TFGLQQQEPQ IPRARQPKAL
TPLMDGI
//
