ID   A0A1H0FKX6_9ACTN        Unreviewed;       391 AA.
AC   A0A1H0FKX6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Threonine dehydrogenase {ECO:0000313|EMBL:SDN95428.1};
GN   ORFNames=SAMN05428965_2080 {ECO:0000313|EMBL:SDN95428.1};
OS   Geodermatophilus sp. DSM 45219.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Geodermatophilus.
OX   NCBI_TaxID=1881103 {ECO:0000313|EMBL:SDN95428.1, ECO:0000313|Proteomes:UP000198730};
RN   [1] {ECO:0000313|EMBL:SDN95428.1, ECO:0000313|Proteomes:UP000198730}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45219 {ECO:0000313|EMBL:SDN95428.1,
RC   ECO:0000313|Proteomes:UP000198730};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; FNIQ01000003; SDN95428.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0FKX6; -.
DR   STRING; 1881103.SAMN05428965_2080; -.
DR   OrthoDB; 3399630at2; -.
DR   Proteomes; UP000198730; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08283; FDH_like_1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          26..148
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          196..265
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   391 AA;  42063 MW;  D683F80D495598BC CRC64;
     MRAATWTGVN EVSVETVPDP TILNDHDVIL KVSRTTTCGS DLHLLGGYIP FMRAGDVLGH
     EFMGEVVEVG RGVRDRRIGD RVVVNSFIAC GKCWYCTQEL YSLCDNGNPN PGITEALWGQ
     SPGGCFGYSH AMGGWAGSHA EYIRVPYADV GAFVVPEGVS DERALFASDA VSTGWMGADL
     AGTKPGDVVA VWGAGGVGQM AARAAMLLGA ERVYVIDRLP ERLAQVREHV GAEAIDYSRT
     DVLAELREVT GGRGPDVCIE AVGMEAHSLG VQGAYDQVKQ QLRLQTDRPS AVREAILACR
     KGGSVFVLGV YAQMVDKFPL GALMNKGLTV RGAQVHGQRY MPRILDHMAR GELTTEHLAT
     HVMPLEDAAR GYRVFKDKAD GCVRSVFLPN G
//