ID A0A1H0FU61_9PSEU Unreviewed; 2499 AA.
AC A0A1H0FU61;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SDN98175.1};
GN ORFNames=SAMN05192558_101516 {ECO:0000313|EMBL:SDN98175.1};
OS Actinokineospora alba.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=504798 {ECO:0000313|EMBL:SDN98175.1, ECO:0000313|Proteomes:UP000199651};
RN [1] {ECO:0000313|Proteomes:UP000199651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBRC-M 10655 {ECO:0000313|Proteomes:UP000199651};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FNJB01000001; SDN98175.1; -; Genomic_DNA.
DR STRING; 504798.SAMN05421871_103355; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000199651; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17652; A_NRPS_CmdD_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000199651}.
FT DOMAIN 478..553
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1008..1082
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2409..2484
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2499 AA; 267892 MW; F351691EB0B51662 CRC64;
MSAHTTLLDL FAHSARAHAE EPALSAEDRT VTYRALDSWS DRLAHKLITL GAGPERLVAL
ALPRSVDMVV AQLAVLKAGA AYLPIDPDYP ADRIRAMVDD ARPLLVVDDP AWVADAGDTA
AVPVRPHPDQ PAYVIYTSGS TGRPKGVVVT HRGLATFATA EVDRFDVRPG DRVLLFSSPS
FDASVLELCM AFAGGAALVV PPPGPLVGEQ LADVLAARAV SHALIPPVVL ATLPDVELPH
LRTLVVGGDA CTAGLVRRWA PGRRMVNAYG PTESTVVSTW SDPLTPGEGA PPIGRAIPGT
EVLVLDDDLR PAEHGELYVA GVGLARGYLD RPGLTAQRFL AAPDGQRRYR TGDVVRRRAG
GDLEFVGRAD HQVKIRGFRV EPGEIEAVLA EDPRVGQAVV VPRTDSGLKR LVAYVVPAGD
DRPDPADLRA VLAARLPDYL VPAAIVVLDA FPLSPNGKLD RAALPAPVVG SAATGYVAPR
DERERVLAGL WADVLGATEV GVEDDFFALG GDSILASRLR SRIIAEFGAE LSGRAVFDAR
TVAALAALLP ATSAHCAPIS PAPSDRPLPL SPAQRRLWLA EITAGGLANN TGAALRLTGD
LDRHALRTAL DRLAARHGAL RTTIDTIAGQ PCQLVAPAPA LPLREVRTTD LHADLARDLA
EPFDLRTGPT TRATLFALGP REHVLLLAQH HLVTDGWSMA LLIDELLACY REATGGAPAV
LAGQSVTYGD FAAWAADRAD HTESLAYWRE RLDGLVPLDL PTDRPRPAVR VGSGGVLRRE
LPADLVRRLS VLGAAHDATL FMTLTAAVQL VLAARAGTRD VAVGAARAGR PRTELDTVAG
FFVNTLVLRS TVDPSAPFSE FLGQVRETAL DAFAHDDAPF DRVVDHLAPE RDASRTPLVQ
AVVALQQPLL RATEAGGLLV AEQDLPRPAS RFDLTVEFWP RGDALTMTAE YDTALFDLAT
IEGIAAEVDR VLRAIADQPD SPLETLVDLS DTGRTPRVAR PTPARYLAPR TPVEATLAQV
YAKVLGAARV GVRDNFFALG GDSILSIQVV AAARAAGVVV TSRDVFTHQT VAALAPHAVA
VDLADRPDNA AVSGSAPLTP IQRWFLDTHT VHPQRFHQSC VVDLGEPVDE AALRAAVAAI
TEHHDALRMR FADTTEQVNA PVGADGAVFG HGPLFTATTI GETTVRLAAH HLVVDGLSWR
VLAEDLRTAH ARARLGLDVR LPGRTTSFRD WARRLATHTA EGGFDHERAH WAHTVQVDGR
VPCATDGSNT VATQREVTVS LTEDETRALV RTVPDAYRTR VDEVLLTALA STLGKWTGRD
RLLVDVEGHG REDLFAGVDV SRTVGWFTTV YPVALPVRPD WGNALKAVKE TVRSVPRRGI
GYGALRHLAG AQDLACAADV SFNYLGRFDG PTGLDLDAHP DAARAHVLDV VGRIEGDRLA
FTWYFSENLH RADTIATLAD TMLAALRDLT GHCANAHGRT PSDFPLVALD QAAVDRLAVP
GVADLLPLTP MQAGMVFHGL SQSGTGAYFQ QTSFVLDDVP DPAALAAAWQ HVVDRTPILR
SSVLWQEEPV LVVHDHVPVP ITILDWTGQD RAANLATLLA ADQRTGFDLD RAPLMRLTIA
RLSPTEVQVL WTFHHVLLDG WSVFGVLADV AAAHAGAPLP ERPDFAEYPR WIAGQDDGEE
HWRPVLAEVT APTPLPFDRP RSSVAQPTTS ARTDVALSVQ ETTALYDFAK AQGLTPGTVV
QGAWALLLAQ YSGQRQVCFG ATVSGRPADL RDVESIIGMF VNTLPVVATV DGAAAVADWL
RELQRGQAGA RAAQHTPLTK LHGWSQVPGG VDLFDSAVIF ENYPMGGPPV RELAAVESTT
FPLSVTVYPT ERLSLLVGYE PGLFDADTAQ ALAEHLVHLL RELTADPDRP VSAVPALSTP
EQVDGWNRTD VDVPATTLTA LLSDQAAKTP DGEALVFEDV RWTYAELHAR ADRLANWLRD
QGAGPERVVA VALPRSAELI VALLAVLKSG AAYLPIDPNL PRQRIDFMVA DAGAVLLLDS
TDLPGTDQPA TAPELDPANG AYVIYTSGST GKPKGVVVPH EGIVNRLLWT QDRFRLGPGD
RVLQKTPMSF DVSVWEFFWP LMVGATLVVA RPDGHRDPAY LAELIRSESV TTVHFVPSML
RAFLRHADLA GCISLRRVLC SGEALPQDLA EDFHAACEAE LHNLYGPTEA SVDVTHWHCE
PGQPTVPIGR PVWNTRLHVL DDELRPVPVG APGELHLAGV QLARGYLNRP GLTAERFIAN
PFEPGRLYRT GDLVRWTRDG AVEYLGRTDH QVKIRGFRIE PGEVESALSA LPEVDEAAVI
ARDGRLVAYV VPATADPAAI RAAVAGVLPE HLVPSAVVAL ERLPLTTSGK LDRRALPDPD
FTAVSADTGP ETGTEKALAE IWAEVLDLDR VGVEDSFFDL GGDSILSLHV TARANAAFGV
ALKPRDVLTA RTVRALATLV EDQVLRELEE LARLDDATE
//
