ID   A0A1H0GVB3_9GAMM        Unreviewed;       427 AA.
AC   A0A1H0GVB3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Nucleoside permease {ECO:0000256|RuleBase:RU362018};
GN   ORFNames=SAMN04487951_11333 {ECO:0000313|EMBL:SDO10833.1};
OS   Halomonas arcis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=416873 {ECO:0000313|EMBL:SDO10833.1, ECO:0000313|Proteomes:UP000199677};
RN   [1] {ECO:0000313|Proteomes:UP000199677}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.6494 {ECO:0000313|Proteomes:UP000199677};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC       (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC       ECO:0000256|RuleBase:RU362018}.
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DR   EMBL; FNII01000013; SDO10833.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0GVB3; -.
DR   STRING; 416873.SAMN04487951_11333; -.
DR   OrthoDB; 9766455at2; -.
DR   Proteomes; UP000199677; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR008276; C_nuclsd_transpt.
DR   InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR   InterPro; IPR011657; CNT_C_dom.
DR   InterPro; IPR002668; CNT_N_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   NCBIfam; TIGR00804; nupC; 1.
DR   PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR   PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR   Pfam; PF07670; Gate; 1.
DR   Pfam; PF07662; Nucleos_tra2_C; 1.
DR   Pfam; PF01773; Nucleos_tra2_N; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199677};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362018};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT   TRANSMEM        6..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        29..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        87..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        167..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        264..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        293..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        362..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        399..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   DOMAIN          8..81
FT                   /note="Concentrative nucleoside transporter N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01773"
FT   DOMAIN          92..190
FT                   /note="Nucleoside transporter/FeoB GTPase Gate"
FT                   /evidence="ECO:0000259|Pfam:PF07670"
FT   DOMAIN          195..417
FT                   /note="Concentrative nucleoside transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07662"
SQ   SEQUENCE   427 AA;  44499 MW;  02C0A91BCC56AD68 CRC64;
     MTLLMSLVGM VTLVTIALIF SYDRKSIRLR TVLGAFGIQA GIGAFVLYVP FGQTVLQTIS
     AGVSQILVYA DDGISFLFGG LADADEVGFV FAIKVLPVII FFSSLIAVLY YLGIMQWVIR
     ILGGALQKAL GTSRTESLSA TANIFVGQTE APLVVRPFIA RMTPSQLFAV MCGGLASVAG
     SVLAGYAALG IPMEYLVAAS FMAAPGGLLF AKLIMPETQD PKDADSVSKV EEELDEQSDK
     PSNVLDAAAT GATSGLMLAA NVGAMLLAFI ALIALINGIL GGVGGWVGFE SLSLEWILGW
     LFAPLAFLLG VPWEEATLAG SFIGQKLVVN EFVAYINLAP YIEGEQVVAA TGQVMTPHTM
     AILSFALCGF ANLSSIAILL GGLGSIAPTR RKEIARFGVK AVLAGTLSNL MSASIAGFFI
     ALGSTAS
//