ID   A0A1H0HB78_9BRAD        Unreviewed;       326 AA.
AC   A0A1H0HB78;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Signal peptide peptidase A. Serine peptidase. MEROPS family S49 {ECO:0000313|EMBL:SDO16141.1};
GN   ORFNames=SAMN05444050_3406 {ECO:0000313|EMBL:SDO16141.1};
OS   Afipia sp. GAS231.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Nitrobacteraceae; Afipia.
OX   NCBI_TaxID=1882747 {ECO:0000313|EMBL:SDO16141.1, ECO:0000313|Proteomes:UP000198617};
RN   [1] {ECO:0000313|EMBL:SDO16141.1, ECO:0000313|Proteomes:UP000198617}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GAS231 {ECO:0000313|EMBL:SDO16141.1,
RC   ECO:0000313|Proteomes:UP000198617};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S49 family.
CC       {ECO:0000256|ARBA:ARBA00008683}.
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DR   EMBL; LT629703; SDO16141.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0HB78; -.
DR   STRING; 1882747.SAMN05444050_3406; -.
DR   OrthoDB; 9764363at2; -.
DR   Proteomes; UP000198617; Chromosome i.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd07023; S49_Sppa_N_C; 1.
DR   Gene3D; 6.20.330.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR004635; Pept_S49_SppA.
DR   InterPro; IPR002142; Peptidase_S49.
DR   InterPro; IPR047272; S49_SppA_C.
DR   NCBIfam; TIGR00706; SppA_dom; 1.
DR   PANTHER; PTHR42987; PEPTIDASE S49; 1.
DR   PANTHER; PTHR42987:SF4; PROTEASE SLR0021-RELATED; 1.
DR   Pfam; PF01343; Peptidase_S49; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198617};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          108..259
FT                   /note="Peptidase S49"
FT                   /evidence="ECO:0000259|Pfam:PF01343"
SQ   SEQUENCE   326 AA;  34906 MW;  DC72D691DDCE53C6 CRC64;
     MSLDSDVIVD RRRIRRKLTF WRVFAAVVAI AAVIAVGLVA TPGGRASLTS SGSIARVNIE
     GLIRSDQERV EALERLEKSQ AAAVIVHINS PGGTTAGSEQ LYDALVRLKA KKPLVVVVEG
     LAASGGYIAA IAADRIIAQQ SSLVGSIGVL FQFPNFTELL KTVGVKVEEV KSSPLKAAPN
     GFEPTSPEAR AALDALVKDS YAWFRGLVKE RRGMDDELLE KVADGRVFTG RQAVELKLID
     QLGDEKAAVA WLVAEKKVKS DLPVRDFKLS PRFGDLTFLR TAASIALDAL GLGTVARQIE
     QAGVAQAVDQ LRLDGMLALW RPAASN
//