ID   A0A1H0HFM3_9ACTN        Unreviewed;       761 AA.
AC   A0A1H0HFM3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Dipeptidyl-peptidase-4 {ECO:0000313|EMBL:SDO17651.1};
GN   ORFNames=SAMN05216259_10828 {ECO:0000313|EMBL:SDO17651.1};
OS   Actinacidiphila guanduensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Actinacidiphila.
OX   NCBI_TaxID=310781 {ECO:0000313|EMBL:SDO17651.1, ECO:0000313|Proteomes:UP000199341};
RN   [1] {ECO:0000313|EMBL:SDO17651.1, ECO:0000313|Proteomes:UP000199341}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.2022 {ECO:0000313|EMBL:SDO17651.1,
RC   ECO:0000313|Proteomes:UP000199341};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNIE01000008; SDO17651.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0HFM3; -.
DR   STRING; 310781.SAMN05216259_10828; -.
DR   OrthoDB; 9812921at2; -.
DR   Proteomes; UP000199341; Unassembled WGS sequence.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199341}.
FT   DOMAIN          98..233
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          550..748
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   REGION          241..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          446..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   761 AA;  81217 MW;  5AC7A54130F3866C CRC64;
     MPTPDALPEQ VATTRRFSLG VPRAITVGAD GRTVLFLRTR AGDDPVACLW ATDADTGAER
     LLADPAGLLE PPDDAGRSGD GIRAYATDRA GRLAVFTFAG SLWAVDVADG RVRRLPASGE
     PAAPRPDPQG RRIAYATGGA LRLIGADGRG DRELAAPQGP EVVHGLGEHT EHGLWWAPDG
     RRLLYARTDF TRVGRWYLAD PSAPWQPPRV LRRSTPGTPL PDVTLWVAEL AASARMGAAR
     TGSGAAGAGA AEAPAESPAE AHAEPLVSPH AESPARPRAE SPSHADAEPL AQLRGGLRTP
     PDAAPFAPPR IQVLWDRAAF AYVVGAGWDA HGPYALVQSR DQRTVRLLAI DPADGTTRVL
     HEQHDPRWVH LVPGLPARTA AGELVTAEER DGTRTLAVAG TPVTPAGLQL GAVLGVEGED
     VLFTASREPA ETHLWTYRPG EGLRRLSREP GVHTGVRGGG TLVHTAGGPD RPGGRTTVRR
     RGSTRAIASL VQQPTLDVRA VRLLLGPRRL RADLHLPSWH RPGTRLPVLA DPYGGAARRR
     VTAERDWRSL VAQWFAEQGF AVLVADGRGT PGRGPQWERA VHGDLFGPAV EDQATAVREA
     ARRFPDLDPG RVGIRGWSFG GALALAAVLQ RPDVFHAAVA GAAVTDQRVY DARWRERFLG
     PPAESLRTYE SNSLLRRAPS LTRPLLLVQG LADTTTHPSH TLRMSAALLA AARPHEVLLL
     PNAGHDAIGS PLTAPLLRHQ LAFLQKHLHP PSRNQAYGGA D
//