ID A0A1H0JDD5_9ACTN Unreviewed; 1072 AA.
AC A0A1H0JDD5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05192576_3994 {ECO:0000313|EMBL:SDO41757.1};
OS Nocardioides szechwanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=1005944 {ECO:0000313|EMBL:SDO41757.1, ECO:0000313|Proteomes:UP000199004};
RN [1] {ECO:0000313|EMBL:SDO41757.1, ECO:0000313|Proteomes:UP000199004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.11147 {ECO:0000313|EMBL:SDO41757.1,
RC ECO:0000313|Proteomes:UP000199004};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FNIC01000008; SDO41757.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0JDD5; -.
DR STRING; 1005944.SAMN05192576_3994; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000199004; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199004}.
FT DOMAIN 24..362
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 363..677
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 97..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 45..52
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1072 AA; 117212 MW; 3E60A771E55CE751 CRC64;
MTATRPALAI DTPEQLRELL DADFTFSDPQ FAAITAPLEP AVVIAGAGSG KTTVMAARVV
WLVATGRVSP AQVLGLTFTT KATAELQTRI RDSLRRAGLL PDRSAPRGDD EDEVEEPTVS
TYHSYASSLL SEHGLRIGHE PDTRLIADAS RYQLATRAVQ RYTTPVAHLS DSPKHVVQYL
LALDAEMSEH LVDPQQVLDL DARHRPLFEA GMATEHRKTY REKNEKAILA GDRRAELVGL
VRAYRRLKTH LGLMDFSDQI ALAARLAAEC PEVGVIEREK FRVVLLDEYQ DTSVAQALML
SRLFSGPSTG RGHPVTAVGD PNQAIYGWRG ASVSNILEFG ADFPAADGSR TSYPLVVNRR
SDARILATAN HLAAELYDTR DDLLPLEPKP GAADGEVRAI VHETYEDELA WLAERVLETH
AALAAASERP AWREIGVLTR DNSHAAAVFD ALSAREIPVE IVGLKGLLRL PEVSEVVATL
NLVQDVTANA ALLTLLAGPR WAVGPRDLAL LGRRAGELAG SRAGGEAFAD VQDQLAAAVE
GADPTEIASL CDALDDPGEL DYSPEARERF GLLADELRRL RSAIGDRILD LVRRIIDATG
IDVELASSVS PAAAARRDNL DLFVQAVAEF QAVDGQVTLS ALLAWLEAED EFGQGLDVAT
PSEADSVKLL TVHRAKGLEW DAVFLVGVTE KKFPNERGRP SWLTVPSVMP TELRGDARDL
PQLAGHTPAD LIALATAAKA HESLEELRLG YVAWTRARHH LSVSAWRWAA HLKGGLGPSR
YLVRTREAMA TWGGEPDAWL ALVAKGETSP YADQVVDQTW PISHHTPEVV RRTEAAAWVR
AADPDATDDI EDVLQLDRVQ QWDDEIARLL AEASRDRTPD IAVPLPSSLS ATSLAKLRDD
PDTFARDLAR PMPRPPSSAA RFGTRFHAWV EARFGQQLLL DPDDLPGRAD TGIEDDADLR
ELIARFESGP FAERPPLEIE PSFALVLDGQ VVRGRIDAVY REGDGFLVVD WKTNRAQTAD
PLQLAIYRLA WAELHDVPLE QVRAAFYYVR TGELVEPGEL PGRDDLEKLL RP
//
