ID   A0A1H0K3S6_9ACTN        Unreviewed;       180 AA.
AC   A0A1H0K3S6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Lysine N-acyltransferase MbtK {ECO:0000256|ARBA:ARBA00020586};
DE   AltName: Full=Mycobactin synthase protein K {ECO:0000256|ARBA:ARBA00031122};
GN   ORFNames=SAMN05192576_4146 {ECO:0000313|EMBL:SDO50559.1};
OS   Nocardioides szechwanensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=1005944 {ECO:0000313|EMBL:SDO50559.1, ECO:0000313|Proteomes:UP000199004};
RN   [1] {ECO:0000313|EMBL:SDO50559.1, ECO:0000313|Proteomes:UP000199004}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.11147 {ECO:0000313|EMBL:SDO50559.1,
RC   ECO:0000313|Proteomes:UP000199004};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acyltransferase required for the direct transfer of
CC       medium- to long-chain fatty acyl moieties from a carrier protein (MbtL)
CC       on to the epsilon-amino group of lysine residue in the mycobactin core.
CC       {ECO:0000256|ARBA:ARBA00003818}.
CC   -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005102}.
CC   -!- SIMILARITY: Belongs to the lysine N-acyltransferase MbtK family.
CC       {ECO:0000256|ARBA:ARBA00009893}.
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DR   EMBL; FNIC01000009; SDO50559.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0K3S6; -.
DR   STRING; 1005944.SAMN05192576_4146; -.
DR   OrthoDB; 5177616at2; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000199004; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0019290; P:siderophore biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.630.30; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR019432; Acyltransferase_MbtK/IucB-like.
DR   InterPro; IPR000182; GNAT_dom.
DR   PANTHER; PTHR31438; LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED; 1.
DR   PANTHER; PTHR31438:SF1; LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED; 1.
DR   Pfam; PF13523; Acetyltransf_8; 1.
DR   SMART; SM01006; AlcB; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199004}.
FT   DOMAIN          21..172
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS51186"
SQ   SEQUENCE   180 AA;  20484 MW;  D176F338E972B261 CRC64;
     MTDSGIRHLR LERFDPARDS PLLHSWVVQE RAQFWMMGEH TLAEVREIYE WIDEQPTHAA
     YLAWADDEPA ALFQTYDPRA EEVGDHFDVR LGDVGVHFML APPTRPRSGF TSTVISFLVD
     TVFADPEVHR LVAEPDARNE KAVNLVVRLG FELGPVVELS TKPAQLAYLD RTSFSNHRSA
//