ID A0A1H0M2Y6_9BACL Unreviewed; 421 AA.
AC A0A1H0M2Y6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=fumarylacetoacetase {ECO:0000256|ARBA:ARBA00012094};
DE EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
GN ORFNames=SAMN04487897_12115 {ECO:0000313|EMBL:SDO74576.1};
OS Paenibacillus sp. yr247.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1761880 {ECO:0000313|EMBL:SDO74576.1, ECO:0000313|Proteomes:UP000198936};
RN [1] {ECO:0000313|EMBL:SDO74576.1, ECO:0000313|Proteomes:UP000198936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR247 {ECO:0000313|EMBL:SDO74576.1,
RC ECO:0000313|Proteomes:UP000198936};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC {ECO:0000256|ARBA:ARBA00004782}.
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DR EMBL; FNIF01000021; SDO74576.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0M2Y6; -.
DR STRING; 1761880.SAMN04487897_12115; -.
DR OrthoDB; 9805307at2; -.
DR UniPathway; UPA00139; UER00341.
DR Proteomes; UP000198936; Unassembled WGS sequence.
DR GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR005959; Fumarylacetoacetase.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR InterPro; IPR015377; Fumarylacetoacetase_N.
DR InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR Pfam; PF09298; FAA_hydrolase_N; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:SDO74576.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Reference proteome {ECO:0000313|Proteomes:UP000198936};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 17..121
FT /note="Fumarylacetoacetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09298"
FT DOMAIN 128..406
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 421 AA; 46703 MW; DC2CE71F7C9A206C CRC64;
MVRSFIEVEP DSHFPIQNLP YGVFRPHKGG QPRIGVAIGN YVLDLAVLDT AGCFEKTAVS
GRNIFSQPSL NALMSFSRPV WKELRSTIGR LLDVEEPALR DNEELRATAM YLQNDVELLL
PVEIGDYTDF YASKDHATNV GSMFRGKENA LMPNWLHLPV GYHGRASSVV ISGSDIRRPQ
GQMKPPDSAA PIFGSSRQLD FELEVGCLIG TGNEQGLPVS IEKAEDYIFG LVLVNDWSAR
DIQSWEYQPL GPFLAKNFAT SISPWVVPLE ALEPFRVPAP KQDPEPLPYL RQSTPGSFNI
QLEVYLQSES MKRPDRISAS NFSYLYWTMA QQIAHHTIGG CNLRPGDLLA SGTISGPEKE
SRGSMLELTW RGSEPLQLIN GDERVWLEDG DCLTMTGWCQ GDGYRVGFGE VIGRVLPAIL
S
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