ID A0A1H0N091_9MICO Unreviewed; 816 AA.
AC A0A1H0N091;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=SAMN04489867_0777 {ECO:0000313|EMBL:SDO86104.1};
OS Pedococcus dokdonensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Pedococcus.
OX NCBI_TaxID=443156 {ECO:0000313|EMBL:SDO86104.1, ECO:0000313|Proteomes:UP000199077};
RN [1] {ECO:0000313|Proteomes:UP000199077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22329 {ECO:0000313|Proteomes:UP000199077};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; LT629711; SDO86104.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0N091; -.
DR STRING; 443156.SAMN04489867_0777; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000199077; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 21..474
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 442..473
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 816 AA; 87171 MW; DB31DA0CD361528C CRC64;
MARKTPAAPS DESYVERIVD IDVEEEMQGA FLEYAYSVIY SRALPDARDG LKPVQRRILY
SMAEMGLRPD RGHVKSSRVV GDVMGKYHPH GDTAIYDALV RMAQPFTMRL PLVDGHGNFG
SLDDGPAASR YTEARLAPAA MLMVTGLDEE TVDFIPNYDD QLLQPGVLPA AFPNLLVNGA
SGIAVGMATN MAPHNLVEVI GAARHLIANP SCSLDDLMRF VPGPDLPQGG RIIGLDGIRD
AYLGGRGSFR TRATTRIEKT SPRRMGIVVT ELPYLVGPEK VIEKIKDAVQ SKKLQGISDV
KDLTDRKHGL RLVIEVKNGF NPDAVLEQLY KLTPMEDSFS INNVALVDGQ PKTLGLKDLL
RVYVDFRTEV VRRRTEFRLT KYKDRLHLVE GLLIAILDID EVIQVIRSSD DAAAARSRLM
DVFDLSEAQA NYILELQLRR LTKFSRLELD KEKSELERLI EELEAILGDE KLLMKTVSTE
LADVAKAHGT PRRTVLLESA GVPATTTTPL EVADDPCWVL LSSTGLMART GSAEPLPLDG
SRSKHDALVG AVRTTARGEV GLVTSRGRLV RLSALELPTL PPTNGSPSLS GGAPLAAYVD
LPAGEEPLTL VSLAPDSPGI ALGTAQGVVK RVTTTDYPAR PDFEVISLKD GDEVVGAVEL
STGTEDLVFI TTDAQLLRFG AGAVRPQGRP AGGMAGIKLG AGQRVAFFGA VPADADAVVV
TSSGSSGALP GTEPGSLKVT PYAEYPPKGR ATGGVRCHRF LKGEDTLVLA WAGALPARAA
AANGVALELP EATGRRDGSG VPAATAIARI AGPPPA
//
