ID A0A1H0P818_9PSEU Unreviewed; 510 AA.
AC A0A1H0P818;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN05192558_1062 {ECO:0000313|EMBL:SDP01247.1};
OS Actinokineospora alba.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=504798 {ECO:0000313|EMBL:SDP01247.1, ECO:0000313|Proteomes:UP000199651};
RN [1] {ECO:0000313|Proteomes:UP000199651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBRC-M 10655 {ECO:0000313|Proteomes:UP000199651};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; FNJB01000006; SDP01247.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0P818; -.
DR STRING; 504798.SAMN05421871_106450; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000199651; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SDP01247.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199651};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SDP01247.1}.
FT DOMAIN 11..204
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 253..483
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 510 AA; 53544 MW; 11AFB8D734AE9330 CRC64;
MTTRARKSPG RVAFVGSGPG DAGLLTVRAR ELLERAELVV TDPDVPSGVL AFARADAEVR
PAVGQPADVA KDLVTEAKAG RVVVRLVAGD PLTHSAVVAE AQAVARTSAV FDVVPGVSAA
TAVPAYAGIA LGSTHTEVDV RGDIDWAGLA GVPGPIVLHA TSSHLAEAAS SLVEHGLAPQ
TPVAVTADGT GSSQRTIDTT LASLAADAGE VSGSLVVTVG AAVAQRSKLS WWESRALYGW
RVLVPRTKDQ AGEMSERLHM HGAIPSEVPT ISVEPPRSPA QMERSVKGLV DGRYQWVIFT
STNAVRAVWE KFAEFGLDAR AFSGVKIACV GEATAEKVRS FGINPELVPS GEQSSEGLLA
DFPPYDDILD PVERVLLPRA DIATETLAAG LRDRGWEIDD VTAYRTVRAA PPPADTREMI
KTGGFDAVCF TSSSTVRNLV GIAGKPHTRT LVACIGPKTA ETAREFGLRV DVQPEHATVP
ALVDALAEHA ARLRAEGALP PPRKTKRARR
//