ID   A0A1H0QCB8_9ACTN        Unreviewed;       411 AA.
AC   A0A1H0QCB8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:SDP14715.1};
GN   ORFNames=SAMN05660199_03279 {ECO:0000313|EMBL:SDP14715.1};
OS   Klenkia soli.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Klenkia.
OX   NCBI_TaxID=1052260 {ECO:0000313|EMBL:SDP14715.1, ECO:0000313|Proteomes:UP000199088};
RN   [1] {ECO:0000313|EMBL:SDP14715.1, ECO:0000313|Proteomes:UP000199088}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45843 {ECO:0000313|EMBL:SDP14715.1,
RC   ECO:0000313|Proteomes:UP000199088};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; FNIR01000010; SDP14715.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0QCB8; -.
DR   STRING; 1052260.SAMN05660199_03279; -.
DR   OrthoDB; 9764638at2; -.
DR   Proteomes; UP000199088; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR   PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SDP14715.1}.
FT   DOMAIN          6..272
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          285..409
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        90
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        366
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        396
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   411 AA;  42438 MW;  798DCC1C30C056D0 CRC64;
     MGLDDVVICS PLRTPVGRFG GVFAGLTATA LAATVLREVV ARTGLQEGEV DDVVLGQCYP
     NGEAPAIGRI AALDAGLGVG VPGLQIDRRC GSGLQAVVYA CLQVGAGAGT VVVAGGAESM
     SQVEHYALGL RTGVRGDGTM LHDRLARARE TAGGIHHPVP GGMLETAENV RREHDVDRLS
     QDAWALRSQQ RAGAAIAEGR FADEVVGVEV PGTRKSPART VTEDEHPRPR TTMADLAALR
     PVMASVDPAA TVTAGNASGQ NDGAALCVVT TRAEADRRGW EPFLALRGWA VAGVPPETMG
     IGPVPAVAAA LARTGLTLAD MDLIELNEAF ASQVLACLAA WESSGQLGED DRERVNVNGS
     GISLGHPVGA TGARILATMA HELKRREGRY GLETMCIGGG QGLAAVFERV S
//