ID A0A1H0RNU3_9BACI Unreviewed; 489 AA.
AC A0A1H0RNU3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Altronate oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00670};
DE EC=1.1.1.58 {ECO:0000256|HAMAP-Rule:MF_00670};
DE AltName: Full=Tagaturonate dehydrogenase {ECO:0000256|HAMAP-Rule:MF_00670};
DE AltName: Full=Tagaturonate reductase {ECO:0000256|HAMAP-Rule:MF_00670};
GN Name=uxaB {ECO:0000256|HAMAP-Rule:MF_00670};
GN ORFNames=SAMN05216565_102291 {ECO:0000313|EMBL:SDP30648.1};
OS Litchfieldia salsa.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Litchfieldia.
OX NCBI_TaxID=930152 {ECO:0000313|EMBL:SDP30648.1, ECO:0000313|Proteomes:UP000199159};
RN [1] {ECO:0000313|Proteomes:UP000199159}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBRC-M10078 {ECO:0000313|Proteomes:UP000199159};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH;
CC Xref=Rhea:RHEA:17813, ChEBI:CHEBI:15378, ChEBI:CHEBI:17360,
CC ChEBI:CHEBI:17886, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.58;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00670};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate
CC + H(+) + NADH; Xref=Rhea:RHEA:19661, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57634, ChEBI:CHEBI:57945,
CC ChEBI:CHEBI:61381; EC=1.1.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000292};
CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC interconversion. {ECO:0000256|HAMAP-Rule:MF_00670}.
CC -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxaB
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00670}.
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DR EMBL; FNJU01000002; SDP30648.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0RNU3; -.
DR STRING; 930152.SAMN05216565_102291; -.
DR OrthoDB; 9768714at2; -.
DR UniPathway; UPA00246; -.
DR Proteomes; UP000199159; Unassembled WGS sequence.
DR GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:RHEA.
DR GO; GO:0009026; F:tagaturonate reductase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR HAMAP; MF_00670; Altron_oxidoreduct; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR023668; Altronate_OxRdtase.
DR InterPro; IPR000669; Mannitol_DH.
DR InterPro; IPR013118; Mannitol_DH_C.
DR InterPro; IPR013131; Mannitol_DH_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR30524:SF0; ALTRONATE OXIDOREDUCTASE-RELATED; 1.
DR PANTHER; PTHR30524; MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE; 1.
DR Pfam; PF01232; Mannitol_dh; 1.
DR Pfam; PF08125; Mannitol_dh_C; 1.
DR PRINTS; PR00084; MTLDHDRGNASE.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|HAMAP-Rule:MF_00670};
KW Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00670};
KW Reference proteome {ECO:0000313|Proteomes:UP000199159}.
FT DOMAIN 18..172
FT /note="Mannitol dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01232"
FT DOMAIN 203..454
FT /note="Mannitol dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08125"
FT BINDING 19..30
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00670"
SQ SEQUENCE 489 AA; 56317 MW; 6B36D79BA6E08F3A CRC64;
MEKLNRNTWK ESKKYPVKVL QFGEGNFLRA FVNWQIDKMN KETDFNGGVV VAQPIEFGLI
DKLNEQEGLY TLFLQGIKNE EAVREHSVID CINYGINPYA NYDQLLEVTE NPELRFIISN
TTEAGITFEE NDRLSDSPQK SFPGKLTALL YHRFNTFAGA EDKGFVILPC ELIDRNGEKL
KEIVLKYIEL WNLELGFKEW VLQSNTFCCT LVDRIVTGYP RDTIDEITTE LGYKDELVVV
GEQFHLWVIE GPQWISDEFP TNQAGLNVKV VNDMTPYRTR KVRILNGAHT AMTPVCYLYG
LDTVGDSMKD EVTRDFIERL IFDEIIPTLD LPEEELKSFA SAVLERFMNP YVNHYLLSIA
LNSMSKFKTR DLPTLIEYHG RTGELPRRLV FSLSALIALY KGKRDSEEIN LQDDDHVMEL
YSSLWKDYDG SEDRIREIVT TVLAYEKNWE LDLTIIPGLT DMVTEFLVKI ERSGMKVAIK
DVTKISLGN
//