ID A0A1H0RV78_9PSEU Unreviewed; 406 AA.
AC A0A1H0RV78;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:SDP33491.1};
GN ORFNames=SAMN05192558_108145 {ECO:0000313|EMBL:SDP33491.1};
OS Actinokineospora alba.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=504798 {ECO:0000313|EMBL:SDP33491.1, ECO:0000313|Proteomes:UP000199651};
RN [1] {ECO:0000313|Proteomes:UP000199651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBRC-M 10655 {ECO:0000313|Proteomes:UP000199651};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNJB01000008; SDP33491.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0RV78; -.
DR STRING; 504798.SAMN05421871_113146; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000199651; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Reference proteome {ECO:0000313|Proteomes:UP000199651};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SDP33491.1}.
FT DOMAIN 5..274
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..404
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 361
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 391
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 406 AA; 42835 MW; 644E207BB3AD09B7 CRC64;
MPEAVIVSAV RSPIGRAGKG SLVDIRPDDL TAQMVRAALD KVPALDPTEI DDLMLGCGLP
GGEQGNNLGR IVSVLLGYDH LPGCTVTRYC ASSLQTTRMA LHAIKAGEGD VFISAGVETV
SRFVKGSSDS WPDTRNPIFD EAVARTKTVA ESGAGEWHDP REDGIVPDAY IAMGQTAENL
ALLKGVTRED MDHFGVRSQN LAEKAIKEGF WAREITPVTL PDGRVVDTDD GPRPGITYEK
TATLKPVFRP DGRVTAGNCC PLNDGAAALV IMSDTKAKQL GLTPLARIVS TGVSGLSPEI
MGLGPVEASK RALALAGLTV NDIDLFEINE AFAAQVLPSA RDLGIPEDKL NVNGGAIAIG
HPFGMTGARI ATTLINSLQW HDKQFGLETM CVGGGQGMAM VLERLS
//
