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Database: UniProt
Entry: A0A1H0S141_9ACTN
LinkDB: A0A1H0S141_9ACTN
Original site: A0A1H0S141_9ACTN 
ID   A0A1H0S141_9ACTN        Unreviewed;       406 AA.
AC   A0A1H0S141;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=SAMN05660199_03710 {ECO:0000313|EMBL:SDP35414.1};
OS   Klenkia soli.
OC   Bacteria; Actinobacteria; Geodermatophilales; Geodermatophilaceae;
OC   Klenkia.
OX   NCBI_TaxID=1052260 {ECO:0000313|EMBL:SDP35414.1, ECO:0000313|Proteomes:UP000199088};
RN   [1] {ECO:0000313|EMBL:SDP35414.1, ECO:0000313|Proteomes:UP000199088}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45843 {ECO:0000313|EMBL:SDP35414.1,
RC   ECO:0000313|Proteomes:UP000199088};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; FNIR01000012; SDP35414.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000199088; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199088};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       97    392       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   406 AA;  42229 MW;  F679C287CA436BBD CRC64;
     MPAPADLLPT ATRIADALLE VQQRVNEQVD ATHAQLLPGV QALLGVEPDG AVDPGDLVDQ
     RITGASAVVT PAAVAALVPL TAASAATTRA GRRAVGAVVR GDDDRLAVIA GPCSIHDPVA
     ALEYAAFLAA MRERHGADLE IVMRTYTEKP RTEVDWKGFA YDPFLDGSSR ISVGLVATRM
     LMAEITALGV PVAAEPLNAL TPQYVDGLVT YNGVGARNVT DQTARERVSG FSSVIGFKNS
     PEGSVDVAVS AVISARSGHD FLGVDRHGVS AQLGTTGNDT GHVILRGDAA GPNYSAEHVA
     DTKRRLAARG LPEVLVVDAS HGNSQKDHVR QVQVVRDLAG QIAGGEQGIR GVMVESNLVA
     GRQDLDRTAP GSLTYGQSVT DACVDLPTTE QLLADLAAAV RARRAG
//
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