ID A0A1H0S818_9MICO Unreviewed; 569 AA.
AC A0A1H0S818;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Non-specific protein-tyrosine kinase {ECO:0000313|EMBL:SDP37900.1};
GN ORFNames=SAMN04489867_2245 {ECO:0000313|EMBL:SDP37900.1};
OS Pedococcus dokdonensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Pedococcus.
OX NCBI_TaxID=443156 {ECO:0000313|EMBL:SDP37900.1, ECO:0000313|Proteomes:UP000199077};
RN [1] {ECO:0000313|Proteomes:UP000199077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22329 {ECO:0000313|Proteomes:UP000199077};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; LT629711; SDP37900.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0S818; -.
DR STRING; 443156.SAMN04489867_2245; -.
DR OrthoDB; 9812433at2; -.
DR Proteomes; UP000199077; Chromosome i.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SDP37900.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000313|EMBL:SDP37900.1}.
FT TRANSMEM 14..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..90
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 261..399
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT REGION 460..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 59784 MW; E15C6E464B1B914A CRC64;
MTLRAYLQIL LKRWRIVVAC LVLVLGSAGT LTYLTPPTYA AYATAFVSIS QAGTADASIY
QSSQFAMQRV KSYTEVVKSP DVLQPVIDDL DLDMSVSDLR QVVAAENPVD TVLIKISATD
AKASRAQAIA NAVSDQLGLV IERLETPREG GQSPVKVTTT VPSALPRSPI SPRIPLNMAL
GLLAGLALGV IVAVIREQQD TTVKGDELEE LTGRAALALI GLNPAVKTQP LITMQGHGRG
VEEFRSLRTT LQFVDVDQPP RVIVITSALA AEGKTTTACN LAIALAQSSL RVCLVEADMR
RPNAATLLGV DGSIGLSNVV AGQIDLADAL MPWHRGLLTI LPAGTTPPDP TRLLGSKNMA
AVLATLRADF DFVIIDAPPI LPVSDAAVLA RAADGAVLVA RYGKTRREQL TSAIADLEAV
KARLIGTALT MVPARGQRDL RGHDEDYAAI AAVSENDWPA AAIPTAPNDG SVADDTKPVA
PTSPAPREPS TDDAGGGTAK DTRGSDGSSA PERDRNGAGD RDRGGRDRDR GDDRGNRDGR
QGAPVSLDPR VVGTSFSKAM KPSGQGRVH
//
