ID   A0A1H0SKZ3_9ACTN        Unreviewed;       897 AA.
AC   A0A1H0SKZ3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=GAF domain-containing protein {ECO:0000313|EMBL:SDP42441.1};
GN   ORFNames=SAMN04487981_122104 {ECO:0000313|EMBL:SDP42441.1};
OS   Streptomyces sp. cf386.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1761904 {ECO:0000313|EMBL:SDP42441.1, ECO:0000313|Proteomes:UP000198720};
RN   [1] {ECO:0000313|Proteomes:UP000198720}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF386 {ECO:0000313|Proteomes:UP000198720};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNHV01000022; SDP42441.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0SKZ3; -.
DR   STRING; 1761904.SAMN04487981_122104; -.
DR   OrthoDB; 118142at2; -.
DR   Proteomes; UP000198720; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd16936; HATPase_RsbW-like; 1.
DR   CDD; cd18773; PDC1_HK_sensor; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR033463; sCache_3.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF13581; HATPase_c_2; 1.
DR   Pfam; PF17203; sCache_3_2; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198720};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          351..516
FT                   /note="GAF"
FT                   /evidence="ECO:0000259|SMART:SM00065"
FT   DOMAIN          534..761
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00331"
SQ   SEQUENCE   897 AA;  95397 MW;  D84D40230BAD6976 CRC64;
     MAGFLGRLRS LLSARTVARQ VFVLQAAIVA LLVVAAVVAL VLQVRTDTER EARNRSLAVA
     EVFANAPGVV EALADPDPPA LLQPRAEAAR RATEVDFIVV MSRDGIRYTH PNPDQIGKRF
     VGTIAPAAAG GIVRETYTGT LGPSVRAVVP VTDGDGDVVG LVAAGVTLAS VGGVVDNQLP
     MLLGAAAAAL ALATAGTALV SRRLLRQTHG LGPVEMTRMY EHHDAVLHAV REGVLILDGK
     RRLALANDEA RRLLGLAADA EGRPCFALGI GRDLAGLFTS GRDATDEVHL AQGRLLAVSQ
     RSTDRDGGPP GSVATLRDTT ELRTMTGRAD VAQERLKLLY DAGLEIGTTL DVTRTSQELS
     DFAVPRFADF VSVDLADPVL RGGEPKQGRT DMRRVAFQGV RDGSPLFPIG ELIHFAPATP
     QAFGFGTGRT VLEADMPAFS GWQEQDPENA RRIVDFGIHA MLTVPLRARG VIMGMATFWR
     ADRSEPFEQD DVAVAEELVA RAAVSIDNAR RFTREHTLAD TLQRSLLPRA LPELSALDVA
     YRYLPAHAAQ GGVGGDWFDV IPLPGARVAL VVGDVVGHGL HAAATMGRLR TAVHNFSTLD
     LPPDELLGHL DELVARIDLD EGDDRSAPVT GATCLYAVYD PSSGLCTLSR AGHLEPALVH
     PDGDVEFPDV PVGLPLGLGG SLPFETAELR LPEGSGLVLY TDGLVEQQGR DIDVGLGLLR
     EALAATPPTH GRTPEATCKA VLEALLPERP RDDVALVIAR TRMLPADRMA SWDVPDDPAA
     VARVRAAATR TLDDWGLTEE AFTTELILSE LVTNSLRHAT GPIRVRLIRD RALICEVSDG
     SSTAPHLRTA AATDEGGRGL FLVAQFAERW GTRYSANGKV IWTEQPLADP AGGPTGL
//