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Database: UniProt
Entry: A0A1H0SSU5_9RALS
LinkDB: A0A1H0SSU5_9RALS
Original site: A0A1H0SSU5_9RALS 
ID   A0A1H0SSU5_9RALS        Unreviewed;       573 AA.
AC   A0A1H0SSU5;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SAMN04488595_109115 {ECO:0000313|EMBL:SDP44783.1};
OS   Ralstonia sp. 25mfcol4.1.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=1761899 {ECO:0000313|EMBL:SDP44783.1, ECO:0000313|Proteomes:UP000199332};
RN   [1] {ECO:0000313|EMBL:SDP44783.1, ECO:0000313|Proteomes:UP000199332}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=25MFCol4.1 {ECO:0000313|EMBL:SDP44783.1,
RC   ECO:0000313|Proteomes:UP000199332};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; FNJO01000009; SDP44783.1; -; Genomic_DNA.
DR   Proteomes; UP000199332; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199332};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      270    404       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      481    550       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     278    285       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   573 AA;  62990 MW;  B28187445E22DD3A CRC64;
     MQDFWQAAAA QLERELTPQQ FKTWIKPLAP VAFDEEAHAL RIAAPNRFKL DWVKSQFSGR
     ITALACEYWE TQVSVHFVLD PAASGRAATY TQQAMQQGGH DGMTPAAMGT GGGAYPGASA
     GMAGQAYGHA PAPHPQSLQA GGYHEHAGQP NGGQPGYGAP ASQVPYPAGP GGMPHRGAAP
     TGHPLQAASH VPMQDMGDID VAQMDASEAS ARSYRVPAQQ PAVAGAQPTD TVHERSRLNP
     ILTFDNFVTG KANQLARAAA IQVANNPGKS YNPLYLYGGV GLGKTHLIHA IGNFMLMENP
     RARIRYIHAE QYVSDVVKAY QRKAFDEFKR YYHSLDLLLI DDIQFFSGKN RTQEEFFYAF
     EALIANRAQV IITSDTYPKE ITGIDDRLIS RFDSGLTVAI EPPELEMRVA ILMKKAAAEN
     VSVPEEVAFF VAKHLRSNVR ELEGALRKIL AFSNFHGKDI TIEVTREALK DLLTVQNRQI
     SVENIQKTCA DFYNIKVADM YSKKRPANIA RPRQIAMYLA KELTQKSLPE IGELFGGRDH
     TTVLHAVRKI ADERGKDAQL NHELHVLEQT LKG
//
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