ID A0A1H0U6W8_9CLOT Unreviewed; 592 AA.
AC A0A1H0U6W8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN04488529_109100 {ECO:0000313|EMBL:SDP62017.1};
OS Clostridium gasigenes.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=94869 {ECO:0000313|EMBL:SDP62017.1, ECO:0000313|Proteomes:UP000198597};
RN [1] {ECO:0000313|EMBL:SDP62017.1, ECO:0000313|Proteomes:UP000198597}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12272 {ECO:0000313|EMBL:SDP62017.1,
RC ECO:0000313|Proteomes:UP000198597};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FNJM01000009; SDP62017.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0U6W8; -.
DR STRING; 94869.SAMN04488529_109100; -.
DR OrthoDB; 9762826at2; -.
DR Proteomes; UP000198597; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR008358; Sig_transdc_His_kin/Pase_MprB.
DR PANTHER; PTHR45453:SF3; HISTIDINE KINASE; 1.
DR PANTHER; PTHR45453; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR01780; LANTIREGPROT.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SDP62017.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 295..347
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 376..587
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 592 AA; 67915 MW; 60E951CB2B213C43 CRC64;
MILNKLFKKS IFYKLFFMNL IILVCIVVSQ LFFQTVYFEK YYLNEKAKDL KIEVNKFSTL
LNYENDKVKI MDYIRTVNKE SGITLAFRSK DYNENINMND YMQSENIIVN DDISGNEYRI
VLGDQFKNVK VKKGDRVETY GMSDDYGYVF LSKIFVNNVE IKPIYDIVPS ELNVAAEILK
PAYSLNSSNS NINVSGVVSN IKYESKSYFI NIDLYLSLDE NNYILNNKNY EAKLKSPSGD
NEILLNSESR GNGSVVAFSN LSQVNDIMGT MNGFYFIIFF IILILVIIIS IVYSKFMIRP
LLDMSKVAKR ISECDFNHNY EVDREDEIGT LGNSLNLISD NLQGALNELK SSNIKLKEDI
NIQSIQEEKR KELVANISHE LKTPITIIQG VIGGIKNGIY TTEMYDDILE ETGKMNDLVK
EMLEISKLES PAFKLKKEPF DLCRVILKEN DKLRSMINKK KLNFNIDIND EAIAVGDEKR
INQVITNLFT NAIKYTPCGE NINLKVELDG KKYKFTIENF GVTLEEEDLK NIWNSFYRGE
KSRNKKYGGT GLGLFIVKII LELHGSNFGV ESGSNSVIFF FDLECYENNL SN
//
