ID A0A1H0UXL5_9CLOT Unreviewed; 739 AA.
AC A0A1H0UXL5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=SAMN04488529_11332 {ECO:0000313|EMBL:SDP70920.1};
OS Clostridium gasigenes.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=94869 {ECO:0000313|EMBL:SDP70920.1, ECO:0000313|Proteomes:UP000198597};
RN [1] {ECO:0000313|EMBL:SDP70920.1, ECO:0000313|Proteomes:UP000198597}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12272 {ECO:0000313|EMBL:SDP70920.1,
RC ECO:0000313|Proteomes:UP000198597};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
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DR EMBL; FNJM01000013; SDP70920.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H0UXL5; -.
DR STRING; 94869.SAMN04488529_11332; -.
DR OrthoDB; 9764149at2; -.
DR Proteomes; UP000198597; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013223; RNase_B_OB_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF08206; OB_RNB; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00357; CSP; 2.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000198597};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
SQ SEQUENCE 739 AA; 85302 MW; ADF2B8D68C4276F5 CRC64;
MGMKKTLLNF MREEAYRPMD IQELVTVFDI SQEEYKPFKK TLKTMEKEGT IIRTKKDKFG
IPERMGLVRG KLQAHQKGFG FLIPETEGER DVFIPSSFMN GAMNGDKILV QVTKEDKNGT
KKREGEVVDI LERGNSKIIG IYEGNKNFGF VVPEDTRLNQ DIFVSKKDKN GAEDGDVVVV
EITRWPDQRR SPEGVVEQVL GKKGDKGLDI LTIIKKYGLP EEFSEKILSY AEGVSETIED
KEYRRRKDLR NMKMVTIDGE DAKDLDDAVS IEKLENGTFK LGVHIADVTH YVREQSPLDK
EAFDRATSVY LLDRVIPMLP RKLSNGICSL NPSVDRLTLS CFMTIDQSGK IIDHEIAETI
INTTARMTYT DVTKILKDKD AELIKKYENL HQDFLDMEEL CAILRNKRMR RGAIDFDFPE
SKIILNELGK PVDIKPYERG IANKIIEEFM LAANETVAEY MHWAHMPFVY RIHEEPDEEK
LTKFKEFVYN LGYGIRWTQD VQPKLLQEVL EKVKGKPEEP VVSKLLLRSM MQAKYSPECV
GHFGLAAKYY CHFTSPIRRY PDLQIHRIIK EHLNAKIDEK RAEKLAVIVD QTSKQSSERE
RVAEQAEREV DDLKKAEYMQ NRIGEEFEGM ISSVTSFGIF VQLPNTIEGL VHITELDDDY
YIYDEAHLCL IGERTKKVYR LGAVVKVKCT KVDIDNREVY FNLTEEEEAP KTEIKANKKL
VDELLEVKEE MKTNYVDEE
//
