ID   A0A1H0ZCH8_9MICC        Unreviewed;       398 AA.
AC   A0A1H0ZCH8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Uroporphyrinogen-III synthase {ECO:0000313|EMBL:SDQ25137.1};
GN   ORFNames=SAMN04489742_0270 {ECO:0000313|EMBL:SDQ25137.1};
OS   Arthrobacter crystallopoietes.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=37928 {ECO:0000313|EMBL:SDQ25137.1, ECO:0000313|Proteomes:UP000181917};
RN   [1] {ECO:0000313|EMBL:SDQ25137.1, ECO:0000313|Proteomes:UP000181917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20117 {ECO:0000313|EMBL:SDQ25137.1,
RC   ECO:0000313|Proteomes:UP000181917};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNKH01000002; SDQ25137.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0ZCH8; -.
DR   STRING; 37928.SAMN04489742_0270; -.
DR   KEGG; acry:AC20117_15915; -.
DR   OrthoDB; 213853at2; -.
DR   Proteomes; UP000181917; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR039793; UROS/Hem4.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR   PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000181917}.
FT   DOMAIN          303..398
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51755"
FT   DNA_BIND        303..398
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ   SEQUENCE   398 AA;  42381 MW;  16851AD6CF152375 CRC64;
     MGAAAAVPAS APAPSQDLTR APDQELRTLV ELPNADALAG FRVGVTSDRR AEDLISALER
     RGAQVLHAPA LRIAPVAEDH LLMQDTAAIL GARPDITLIT TAYGMRRWCE AADAHGLGED
     LMDILAASRI FVRGPKARGA VRAAGLDDAG ISHDERTATM VDMLLEQGVE GLTVAIQLHG
     YTDAEQLARL RGAGATVLTV TPYRWIKPEG AEGKVGRLIE AVITRQLDVV TFTSAPAVDA
     LWSTAHELGL FDALVTAFKY DVVAAAVGPV TAKPLEDAGV RPIMPERYRM GALIRLVVEH
     LSGNQIQRFN TALGELEIRG RSVILRGERV DLSPTPLAIF RALAAAGGAV LPREALLECL
     PDAPGEHALD MAVSRLRQAL PDASLVATVI KRGYRLNV
//