ID   A0A1H0ZWI4_9ACTN        Unreviewed;       326 AA.
AC   A0A1H0ZWI4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000313|EMBL:SDQ31778.1};
GN   ORFNames=SAMN04489764_0184 {ECO:0000313|EMBL:SDQ31778.1};
OS   Thermostaphylospora chromogena.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Thermostaphylospora.
OX   NCBI_TaxID=35622 {ECO:0000313|EMBL:SDQ31778.1, ECO:0000313|Proteomes:UP000217103};
RN   [1] {ECO:0000313|EMBL:SDQ31778.1, ECO:0000313|Proteomes:UP000217103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43794 {ECO:0000313|EMBL:SDQ31778.1,
RC   ECO:0000313|Proteomes:UP000217103};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR   EMBL; FNKK01000002; SDQ31778.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H0ZWI4; -.
DR   STRING; 35622.SAMN04489764_0184; -.
DR   OrthoDB; 3505012at2; -.
DR   UniPathway; UPA00796; UER00771.
DR   Proteomes; UP000217103; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0048040; F:UDP-glucuronate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:InterPro.
DR   GO; GO:0033320; P:UDP-D-xylose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05230; UGD_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR044516; UXS.
DR   PANTHER; PTHR43078:SF6; UDP-GLUCURONIC ACID DECARBOXYLASE 1; 1.
DR   PANTHER; PTHR43078; UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000217103}.
FT   DOMAIN          6..232
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   326 AA;  35656 MW;  8AB8EFBD05C05F80 CRC64;
     MSGPTIVITG GAGFLGSHLC ERLLAQGARV ICMDNFLTGS PRNVEHLMTN PAFRVVECDL
     TGFIHVPGEV DMVLHFASAA SPADYLRHPI ETLKVGSLGT LHALGMAKEK GARFILASTS
     EVYGDPLEHP QAETYWGNVN PVGPRSVYDE AKRFAESLTT AYRNSHGVDT GIVRIFNTYG
     PRMRPHDGRA IPTFIRQALR GEPITVTGDG SQTRSICYVD DTVAGVLTLA FDDFAGPVNI
     GNPQEVSMLA LAEIIRDLAG SSSPIRLVER PVDDPKVRCP DTTLAAERLG WRPRVDMIDG
     LRRTIAWFAE ELERESRELT TSRADR
//