ID A0A1H1C281_9ACTN Unreviewed; 463 AA.
AC A0A1H1C281;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN04489765_0978 {ECO:0000313|EMBL:SDQ58251.1};
OS Tsukamurella pulmonis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Tsukamurellaceae;
OC Tsukamurella.
OX NCBI_TaxID=47312 {ECO:0000313|EMBL:SDQ58251.1, ECO:0000313|Proteomes:UP000183053};
RN [1] {ECO:0000313|Proteomes:UP000183053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44142 {ECO:0000313|Proteomes:UP000183053};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FNLF01000002; SDQ58251.1; -; Genomic_DNA.
DR RefSeq; WP_068566976.1; NZ_UHII01000001.1.
DR AlphaFoldDB; A0A1H1C281; -.
DR STRING; 47312.SAMN04489765_0978; -.
DR OrthoDB; 9786919at2; -.
DR Proteomes; UP000183053; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45436:SF5; SENSOR HISTIDINE KINASE TRCS; 1.
DR PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SDQ58251.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 153..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 178..231
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 253..463
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 463 AA; 49445 MW; E3DD740AAE0EBBA1 CRC64;
MGSTSFASRV PLRVSLVALV VGLVLLGLLA SGAALTAAMK DQLISREDQA LRQAAETWAR
PKPVILSQAP RGGPPTRFYQ AVFLPDGRQL QISNPDFTER PDLSGLGDLR GDAVTVQSVG
GHGPQWRVVQ SSSDYGVAFV AVTLTDVDDT LQAMIVLELL IGAGVLIVAG GLGYLVVRRS
LRPLEQVEAT AEAIAAGDLT RRVPQAPAYT EVGRLSTSLN TMLHQVQDSF HRVAASEEQA
RADEQRMRRF VGDASHELRT PLTSIRGFAE LYRQGATDDT GFVMSRIESE AQRMGLLVED
LLLLARLDAR RPLAEDPVDL VAVADDAVHA AQAREPGRDI ALEAGAETVG LMGDRDRLHQ
VVTNLVSNAL RHTPDDASVR VRIAEEPGAV VLSVADTGPG MEPDEAARVF ERFYRTDSSR
SRGSGGAGLG LSIVHGIVER HGGTVTLETA PGAGATFTVR LPR
//
