ID A0A1H1CD35_9ACTN Unreviewed; 761 AA.
AC A0A1H1CD35;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=3-oxoacyl-[acyl-carrier-protein] synthase II {ECO:0000313|EMBL:SDQ62094.1};
GN ORFNames=SAMN04489765_1147 {ECO:0000313|EMBL:SDQ62094.1};
OS Tsukamurella pulmonis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Tsukamurellaceae;
OC Tsukamurella.
OX NCBI_TaxID=47312 {ECO:0000313|EMBL:SDQ62094.1, ECO:0000313|Proteomes:UP000183053};
RN [1] {ECO:0000313|Proteomes:UP000183053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44142 {ECO:0000313|Proteomes:UP000183053};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004796}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; FNLF01000002; SDQ62094.1; -; Genomic_DNA.
DR RefSeq; WP_068566771.1; NZ_UHII01000001.1.
DR AlphaFoldDB; A0A1H1CD35; -.
DR STRING; 47312.SAMN04489765_1147; -.
DR OrthoDB; 9808669at2; -.
DR UniPathway; UPA00915; -.
DR Proteomes; UP000183053; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 3.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 1..391
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 761 AA; 75775 MW; 2FE002E598A3CFF9 CRC64;
MPAVVVTGVG LISAAGSTAQ QCWDTLLSGA TGIVPNTVFP TDDLQAAIAG VAPLPEGEEQ
ELDRCYRLAR RACAEALAHA GLGRADAARA GLVLGSSLGA MPSLEDFHRD VLAAGAVRDR
AAARAGIDTQ LHCAADYVAG EFGLGGPRVV TSNACAAGAV ALGYAAELLW RGDADVVICG
GVDPLTTLSA HGFSSLGALA ESPCSPFAAS DGLSLGEGAG FLVLESEEHA RARGAAPLAR
LAGYDLSSDG FHQTAPDPGG DGARRAMEGA LAAAALGPGT VDYVNLHGTG TPTNDAVEPK
AIRSVFDAPP PVSSTKSVVG HTLGAAGAVE AVVGVLALTD GVLPPTVGTR GDAERTGLDI
VPDRAREAPV RTVLSNSFAF GGNNAAVVLR HAAEPAGAAD AAAQEAPVIT GIAALAGSAQ
STAEVLAALR TGEPVHEQLG PLRFARLDQA AVARRINPAK VRKMDPMSVF AAGAVADLHA
AFGKPDRAGL ARAGIVLGTG YGPLSAVAEF HRGVVEHGSA GANPTVFANT VQNAAAGHLS
VLHRYRGFTA TLTCGGTSTV SALYLARAAL ARGQADRIVV VVVDEFPELA AQVYGATGNA
RHGALGEAAV ALTVERADTA RARGAAPLAS LAGIGMAGEP AGIGRVGGDP AAWAHALTRS
LKDAGPGEPD LVGAAATGHR TIDGAEAAAL DAAGLAAVAR STPKAVLGET VGSAGALALL
DGIDRLRDGG RLVVSSYALG GSYQAAVFDV PAGRPDPEGA R
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