ID A0A1H1DY45_9BACI Unreviewed; 494 AA.
AC A0A1H1DY45;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05216231_2637 {ECO:0000313|EMBL:SDQ81415.1};
OS Virgibacillus salinus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Virgibacillus.
OX NCBI_TaxID=553311 {ECO:0000313|EMBL:SDQ81415.1, ECO:0000313|Proteomes:UP000199444};
RN [1] {ECO:0000313|EMBL:SDQ81415.1, ECO:0000313|Proteomes:UP000199444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.10449 {ECO:0000313|EMBL:SDQ81415.1,
RC ECO:0000313|Proteomes:UP000199444};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FNKD01000003; SDQ81415.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1DY45; -.
DR STRING; 553311.SAMN05216231_2637; -.
DR Proteomes; UP000199444; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000199444};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..134
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 147..458
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 455..489
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 494 AA; 55777 MW; D924A4EDAF7E4672 CRC64;
MSKLTLPQLE SHLWESANIL RGSIDSSDYK NYIFGLLFLK RLSDDFVETA ETIEQEEGDD
YAWYDRDEHQ FFVPDRARWK HIQSQTQDIG NTINKAFEAL EEENTSLEGV LASIDFNDKE
KLPDKLLLQL VQHFSSIDLS TGNLSEPDML GRAYEYLIKQ FADDAGKKGG EFYTPSKVVE
LIVNLIKPEE GMRVCDPTAG SGGMLIQSVD YIKSEGGDPR NLSLHGQERN LSTWSICKMN
LLLHGLSDHQ IERGDTIREP KLIAEDGELS LYDRVIANPP FSLKNWGREE ADSDEYGRFR
FGIPPKNAGD YAFIQHMIST LNDKGKAGVV MPHGVLFRGG AEGEIRQGIL DNNLLEAVIG
LPPNLFYGTG IPACILIFNK DKSDKINNSV FFVDASLSFE KGPNQNKLSE EGIIKIVNTV
SEYTEIDKYS RIVPLKEIKE NLSNLNIARY VDTTTEEEFI NIQSAINDLN ELEKERNDEI
NELNSYLSEL GYHV
//
