ID A0A1H1HAL5_9BURK Unreviewed; 3751 AA.
AC A0A1H1HAL5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SDR22076.1};
GN ORFNames=SAMN05443245_3661 {ECO:0000313|EMBL:SDR22076.1};
OS Paraburkholderia fungorum.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=134537 {ECO:0000313|EMBL:SDR22076.1, ECO:0000313|Proteomes:UP000183487};
RN [1] {ECO:0000313|Proteomes:UP000183487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GAS106B {ECO:0000313|Proteomes:UP000183487};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FNKP01000002; SDR22076.1; -; Genomic_DNA.
DR Proteomes; UP000183487; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1034..1109
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2099..2173
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3651..3726
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1113..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3751 AA; 408703 MW; 70602D8FBDEC0A72 CRC64;
MTQPNPQMLA LSRRYAALPP ERRAEFRQRV AAQSIDPATL PVVPIAAAEN TAPLSFEQEQ
LWFLWKLQPD NPAYHMPGAI ELDGELDIAA LDLALRHVAR QHQSLMTRFV QRADGEPRQT
IDGTPWPQCR VHDLRDAQGQ VESSALDAAL RRAVAEPFDL EAGPPMRTDL FRIGASRHVL
QLTLHHIITD GQSMTVLIRA LAQAYQNASN GTLTHDPAPD ALQFRDCATW QREWLDDTAL
QTHIDYWRAQ LGTHTPPSPL PFDRPRAHRP DAAGGRITRE IDTSLLTNLQ TQARAQGATL
FMTLLAAFGA LLYRYSSETD LRIGVPSSGR DGVETENLIG YFVNTLVVRQ QLSGNLPFDT
LLAQTRQTLL DAQAHRAVPF ARLVQALQAS RNDDTPLFHA MFSMQRSDRA ALLSLPGLSV
TTREIDSGAA QFDLSFNLVE HDRGARLNVV YASGRFDAST IGRLTAHYLQ LLEQLSRDTS
RCIADLSLSD DAPAPVAQQK PEAPRDVLSR ITDHVRARPD AQAVTGETGA LSYRELDDWS
NRIARRLAAQ SGASAMTDTR IGLCTGRSLA LVAGALGILK AGAAYVPLDP RYPLERLQDT
LLDSSVRCIV ADADGVATLG EWAAAHNVTL IDASNLQTPG SDDSRDTSPL QTQLHPEQLA
YVIYTSGSTG KPKGVGVTHA NLARLFDSTA SQFNFGCNDV WTLFHSHAFD FSVWELFGAL
VHGGRLVVVP YWTAREPAAL QRLLREQRVT VLNQTPSAFN ALMQADLHAH EPFGDVRVVV
FGGERLEPAA LAAWHRTRGD DAPALVNMYG ITETTVHVTR RVLHDDDIHG AANALSSPIG
SALDDLQLHL LDADLNPVPR GAKGELYVGG AGLARGYLNR PSLTAERFIP DPFGQPGARL
YRSGDIARRL AGGDLAYQGR NDAQVKLRGF RIEPGEVRAA LLKHPEIASA EVIAREHPQR
GTQLIAYLVA RHDPATLAQS ARDYAAAHLP AHLVPSAFVV LDALPLTING KLDRHALPAP
DDEAFATERN ENAAPLSAVG HKLGELWREV LGVAHVDSND DFFARGGHSL LAVRLAARIE
QSFGVQLPLR VFFDHPRLGA LAAQLETAGT IAQEQTPAQT PRAPLERRPA EQNRVPLSHA
QERLWFLWQY DPQDTAYNIT CAVNLHGALD VAALRSAFDA LSLRHEALRT SFGEEDGVGY
QQIHAEPRCV WSARDLRTCT PETRENEVMS LLRAAASLPF DLTRDPLLRV TLIQSDDDQY
VLHLTLHHII GDGESVDLLI GELVALYRTA HAHGDITCVL PELRVQYGDY ARWQRLHADD
AVLDKQLAYW RGLLGETDPV LELPLKQPRA AQRRRKLGRT VRTLDAARIR ALRQVADGQQ
ASLFIVMLAA FDVLLQRYSG QNEIRVGVPV TGRTQIETGA MIGCFVNTLV MSADLGAADT
FAALIDHVRQ RALDAHAHAD LPFARLVEAL QPNRERNTTP LFQVMINYQQ AAEASTHTLP
GLLIEPLAQQ ADAVQFDLKL DIAGAADHAR LHFDFADDIF AASTIERMAD HFVEILDWLV
AGPDLALRSL TLSAPKREAV PLGGYAFVPV VQRIAETASS RPDAIAVRGE GISLTYRELM
AWASAIAERL AHDGVEPDSC VAVCVARGPS LLAAMLGVWM AGAAYLPVDP AYPADRIAAM
LDDAEVLHVL ADTHSSEHAF AARNVVDVRA LHAGLAAGTY ESNGRTEFHA PPALATIHPD
QLAYVIYTSG STGKPKGVGV THGALDRLVA SIELSPGLRD DDLWLSESAP VFDISLLEFC
LPLVRGVPLE MVSSQTARDG FALAARLEAS QATVFQATPS GWRMLLEAGW RDDLSVAHRP
LLGLSGGEPL HPDLAAALIA RGVSLWNLYG PTETTIYSSG AQVFADQPIT HGDPLPETVL
RVIDQHGIAV PDGGLGELCI GGSNLARGYL RRPGLTAERF VPDPDGAPGA RLYRTGDLCR
LNNEGRPQPL GRLDQQIKLR GFRIEPGEIE AALCACEGVK NAAVAIKGEG SRQRLIGYVT
GTAQGATLRT QLSRTLPAHM LPSTIVTLDA LPLTPSGKLD RRALPEPAWE NDDNSQAIAP
RSPREAALLD IWQTVLGHPV HSVDVNFFEA GGDSILSLQL ISRVRSAGWH LTPKQVFEHP
TIAQQAQLMT ARSDESNRAV ERHDALPLTP IQAAFFARRP DGESHWNQSV LLDAAEPLDL
ARLADALNGL VRRHDALRLR FTRGENGWQQ QVAPRENATL LRHIALDSVD WDNALAREGA
AIQQSLDIEH GPLVRAGYFE AGPRRRLLIA IHHLAVDGVS WRVLLDDLRS LYAGQPLSAP
TAPWSAWVAA QASAASPDIA ELDYWHRTLS VGQPALPAEL MHGHRGYVDS TADRSLAASR
TISVELDAAA TRDLLQNTSH AYRTRADDLL LAALAHTLGA ASPGDTAPML IDIEGHGRST
PIDTIDPSQT VGWFTVQYPF ALPRAPASTA TFATTLIAVK EALRRVPEQG FNFGRLRDER
TSVANGNNEA KHPQLAAWPG AQLRFNYLGQ FDQALADTHT ANPADNAPRL RFSHEFAGAP
LAGGDTMEHL LDITALVVDG VLDLHWRFSP DVLNHTAVQH LAAQTVQALR ELIAHCVDAS
SGATAADFPL ARIDQNTLDA MRLPLHDIDD IYPATPLQQG LLFHSLLTAG AGMYLNQLRL
TLDGTLDPRA LQAAWQDMLD LHPVLRTHFE LGQESGPLQV VHRQAVLPFA VHDWRNVDAK
PDANQDANDN YETRLAQWLA NDLRTDFDPS RAPLMRVALF ARPDGAHDLV WTSHHALLDG
WSSAQLLNAL TGSYRSRVRD DASPATSTPT VAYRDYVRWL AHDDATRNHA DWWRELSAEA
DEAALLTPSL GRPLQSEPGS HDWATRLPDA LHANLQQAAQ RAQVTLNTLM QGAWAILIAR
YGGRRRAAFG VTVSGRPADL PGVERMMGLF INSVPLWVDT RADAPTAAWL RELHTLNHAM
REHEHTPITR IQQWTGRSGD NLFDTLFVFE NYPLDRALDA SDNDLTIRAL RSADRTHYPL
TLAVLPRERL DLQWAWDGER VGRASVERLA ADYERVLTQL ASAVLDVGRD TNDAARVARI
GDIALSSDTF DTQPQRVYDF DPVMPRFNAR AATQPDAIAL ACRGLTLSYR ELDDWSARIG
RQLDRAGLHG DQRVGVCVTR GVGLPAALFG IWKAGGAYVP LDPAYPRERL SGMLDDAGVR
HVVADAACIE QLGSLFDGRE VICIDSAACL GDDAGNPLPA PGWHRPVAPD QLAYVIYTSG
STGKPKGVAL SHRALSLHLA DFQSVYAIDA GDVVLQSSTI NFDVALHELL PALLQGGRVE
MRGPDAWDLD SLNATLVDAG VTFARIPTSL WQQWQRAAPP AAQLRALRQI TVGGEALAGD
TLARWLAGPL AAIRVDNLYG PTETAVAALY HRTSASDTSH VIVPIGRPYP GRGVALLDED
GLRVPQGGLG ELCISGDCLA RGYLGRPGLT AAQFVPDPDG TPGARLYRTG DLCRIGADGT
VQFLGRIDQQ IKLRGQRIEP GEIEAALRSC AGVTQALVAL HGEGEHQRLI AYLVGEFDTA
TLQQTLSTRL PDAWMPGAFV RLDRLPLMPN GKLDRRALPP PEPLTDAPAV APRDPVEQTI
ADIWQDALGV PQVFVHDNFY ALGGHSLLAV QIAARLTRAL QRPVPLATVL AQATVAKLAD
YLRESAEGGA QTQATQAAQR DTMKQLLAEL D
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