ID A0A1H1HBW6_9ACTN Unreviewed; 555 AA.
AC A0A1H1HBW6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=SAMN04489765_4011 {ECO:0000313|EMBL:SDR22861.1};
OS Tsukamurella pulmonis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Tsukamurellaceae;
OC Tsukamurella.
OX NCBI_TaxID=47312 {ECO:0000313|EMBL:SDR22861.1, ECO:0000313|Proteomes:UP000183053};
RN [1] {ECO:0000313|Proteomes:UP000183053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44142 {ECO:0000313|Proteomes:UP000183053};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; FNLF01000002; SDR22861.1; -; Genomic_DNA.
DR RefSeq; WP_068564438.1; NZ_UHII01000001.1.
DR AlphaFoldDB; A0A1H1HBW6; -.
DR STRING; 47312.SAMN04489765_4011; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000183053; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
FT DOMAIN 192..346
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 397..548
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 555 AA; 61327 MW; A1BEAF070E70410A CRC64;
MTDGPLIVQS DKTLLLEVDH ELADAARAAI APFAELERAP EHVHTYRVTP LALWNARAAG
HDAEQVVDAL VNYSRYPVPQ PLLVDVVDTM SRYGRLQLVK HPAHGLTLVS LDRAVLEEVL
RHKKIAPMVG ARIDDDTVVV HPSERGHLKQ LLLKVGWPAE DLAGYVDGES HPIALDTDSH
PWELRDYQKI AADSFWLGGS GVVVLPCGAG KTMVGAAAMA RAQATTLILV TNTVAGRQWK
RELLARTSLT EEEIGEYSGE KKEIRPVTIA TYQVLTRKSK GEYKNLDLFD SRDWGLMIYD
EVHLLPAPVF RMTADLQSRR RLGLTATLVR EDGREGDVFS LIGPKRYDAP WKDIEAQGWI
APADCVEVRV TLTENQRMQY ATAEPDERYQ LASTAPTKVA VVKSILERHK GAPTLVIGAY
LDQLEELGRE LDAPVITGSV KNKEREALFD RFRSGEISTL VVSKVANFSI DLPEASVAVQ
VSGTFGSRQE EAQRLGRLLR PKHDGGTAHF YSVVSRDTLD ADYAAHRQRF LAEQGYAYRI
VDADDILGPA IGEAG
//
