ID A0A1H1HQ44_9ACTN Unreviewed; 473 AA.
AC A0A1H1HQ44;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Membrane-anchored mycosin MYCP {ECO:0000313|EMBL:SDR27581.1};
GN ORFNames=SAMN04489765_4463 {ECO:0000313|EMBL:SDR27581.1};
OS Tsukamurella pulmonis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Tsukamurellaceae;
OC Tsukamurella.
OX NCBI_TaxID=47312 {ECO:0000313|EMBL:SDR27581.1, ECO:0000313|Proteomes:UP000183053};
RN [1] {ECO:0000313|Proteomes:UP000183053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44142 {ECO:0000313|Proteomes:UP000183053};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; FNLF01000002; SDR27581.1; -; Genomic_DNA.
DR RefSeq; WP_068530813.1; NZ_UHII01000001.1.
DR AlphaFoldDB; A0A1H1HQ44; -.
DR STRING; 47312.SAMN04489765_4463; -.
DR OrthoDB; 9798386at2; -.
DR Proteomes; UP000183053; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR023834; T7SS_pept_S8A_mycosin.
DR NCBIfam; TIGR03921; T7SS_mycosin; 1.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..473
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038486641"
FT TRANSMEM 444..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..400
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 253..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 47680 MW; 7D5FEEB2DE78153F CRC64;
MLRFPRAAAI TAVSVSVIVA GSWAPALSGA VVPPVADIGG APPDTDGPER PLRNNNPRCV
EPAVLPNSNL AAAPAPANTL RIDEAHDFST GAGVTVAVLS TGVRPQARLR GLDGAGDNMV
AGDRGLLDCD STGTLVAGIV GAQPVAGDGF VGVAPDARIL SIRVDSAGFS LQNNPAEDAD
PNLSRAAVNA RSIARAIVRA ANRGAKVIVV PEPVCMAADN QFRQREIGGA VAYALRAKDS
LVVVGAGATD RQGGTVGAST CRANPDPDPG RPDDPRGWRQ VSTVATPNWF DGQVLSVGAT
TAEGTPLPGS LNGPWMDVAA PGAGIVSLSS RGGDGVVNGA PSERTLVPFA GPEFAAAYAA
GTAALVRSRY PQLSATEVAA RLVATAHAPG RGTDNEVGRG LIDPVAALTA KVPDIDTAID
PESVEKLLVP PPPPAPDTRP RRTAAIVTGA GAVALLAIGG AVALLRPGRK RRA
//
