ID A0A1H1IUQ1_9BURK Unreviewed; 313 AA.
AC A0A1H1IUQ1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:SDR41437.1};
GN ORFNames=SAMN05443245_5711 {ECO:0000313|EMBL:SDR41437.1};
OS Paraburkholderia fungorum.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=134537 {ECO:0000313|EMBL:SDR41437.1, ECO:0000313|Proteomes:UP000183487};
RN [1] {ECO:0000313|Proteomes:UP000183487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GAS106B {ECO:0000313|Proteomes:UP000183487};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNKP01000002; SDR41437.1; -; Genomic_DNA.
DR RefSeq; WP_074770730.1; NZ_FNKP01000002.1.
DR AlphaFoldDB; A0A1H1IUQ1; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000183487; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732:SF385; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE A; 1.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE 4: Predicted;
FT DOMAIN 32..290
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 57
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 119
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 86
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 313 AA; 34765 MW; 21BC3E2CAC11C173 CRC64;
MNESADFRSK EIVLEHGRGR MPALGFGTLI ADAATTVSAT RDALKAGYRH FDCAERYRNE
REVGEALRVE LAAEGIARED IFVTTKLWNS NHRPERVGPA FHASLERFGL DYLDLYLIHT
PFAFQPGDEQ DPRDENGQVI YDEGVTLLET WQAMESLVDN GKCGAIGLSD IGLKELQPLY
ESARIKPAVV QVEAHPYLPE TELLEFCKEN GIAFLAFAPL GHGIRPGPLE DPVILRIAAQ
LGRTPAQVLL AWAIQRGGAL LTTPKTAARS RENFDISALP AEAFDEINRI ETRQRYNEVV
KTGSPGFIPR RTQ
//
