ID A0A1H1KX28_9FLAO Unreviewed; 586 AA.
AC A0A1H1KX28;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Phenylalanine-4-hydroxylase {ECO:0000313|EMBL:SDR66562.1};
GN ORFNames=SAMN05216503_0176 {ECO:0000313|EMBL:SDR66562.1};
OS Polaribacter sp. KT25b.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=1855336 {ECO:0000313|EMBL:SDR66562.1, ECO:0000313|Proteomes:UP000199117};
RN [1] {ECO:0000313|Proteomes:UP000199117}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT25b {ECO:0000313|Proteomes:UP000199117};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; LT629752; SDR66562.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1KX28; -.
DR STRING; 1855336.SAMN05216503_0176; -.
DR Proteomes; UP000199117; Chromosome i.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR CDD; cd00361; arom_aa_hydroxylase; 1.
DR Gene3D; 1.20.58.690; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199117}.
FT DOMAIN 1..346
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 135
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 140
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 225
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 586 AA; 66247 MW; 39D93772311FF6AD CRC64;
MKSLTSMRFE INEITKKLPI HLHKFVVKQP YNEYTTQNQA VWRYVMRMNV DYLSKVAHKS
YLSGLKKTGI SIDTIPRMEG MNRILKEIGW AAVSVDGFIP PNAFMEFQAY NVLVIASDMR
TINHIAYTPA PDIIHEAAGH APIIANPEYA EYLRRFGEIG SKAISSAKDY EMYEAIRLLS
ILKEDPNSSE KEINEAQEKV EWLQNNMGEL SEMAQIRNLH WWTVEYGLIG TLENPKIYGA
GLLSSIGESD WCMQDEVKKL PYSIEAANIN FDITKPQPQL FVTPDFAYLS LVLDEFANTM
ALRTGGLNGV KKLINSENLG TVELSTGIQI SGAFTKVIQY KNNKVAYLQT TGATALSNRD
KELIGHGISS HASGFGSPVG KLKGINLPIE DMSPRDLRAY GIYEGEFMTL EFESGVIVKG
KAITGTRDLR GKILIISLDE CTVTYKDEIL FQPEWGIYDM AIGKEVISVY AGAADVNSFE
DKSKVSDVKT HKILYSESEK ELYDLYDQVK QMREANSTSE KKITEIFNQL KNKFSNDWLL
NLEIYELALQ NKYALKVEIL KRLEELKCNK SYTKLIENGL VLCKNK
//
